PDB entry 5j71

View 5j71 on RCSB PDB site
Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS35
Class: Transferase/Transferase Inhibitor
Keywords: GHKL protein kinase, pyruvate dehydrogenase complex, Mitochondrial protein kinases, Impaired glucose oxidation, Hepatic steatosis, Type 2 diabetes, Cancer, Bergerat nucleotide-binding fold, protein Kinase, Transferase-Transferase Inhibitor complex
Deposited on 2016-04-05, released 2017-01-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-01-25, with a file datestamp of 2017-01-20.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5j71a1, d5j71a2
  • Heterogens: TLA, P35, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5j71A (A:)
sknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimke
inllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvv
ptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkh
igsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyh
mlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsym
ystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstds
verlpvynksawrhyqtiqeagdwcvpstepkntstyrvs

    Sequence, based on observed residues (ATOM records): (download) 
    >5j71A (A:)
slagapkyiehfskfspsplsmkqfldcektsftflrqelpvrlanimkeinllpdrvls
tpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvley
kdtygddpvsnqniqyfldrfylsrisirmlinqhtlifhigsidpncnvsevvkdaydm
akllcdkyymaspdleiqeinaansqpihmvyvpshlyhmlfelfknamratveshessl
ilppikvmvalgeedlsikmsdrgggvplrkierlfsymgyglpisrlyakyfqgdlqlf
smegfgtdaviylkalstdsverlpvynksawrhydwc