PDB entry 5j6a

View 5j6a on RCSB PDB site
Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS46
Class: Transferase/Transferase Inhibitor
Keywords: GHKL protein kinase, pyruvate dehydrogenase complex, Mitochondrial protein kinases, Impaired glucose oxidation, Hepatic steatosis, Type 2 diabetes, Cancer, Bergerat nucleotide-binding fold, protein kinase, Transferase-Transferase Inhibitor complex
Deposited on 2016-04-04, released 2017-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5j6aa1, d5j6aa2
  • Heterogens: P46, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5j6aA (A:)
    sknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimke
    inllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvv
    ptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkh
    igsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyh
    mlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsym
    ystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstds
    verlpvynksawrhyqtiqeagdwcvpstepkntstyrvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >5j6aA (A:)
    aslagapkyiehfskfspsplsmkqfldfgscektsftflrqelpvrlanimkeinllpd
    rvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqg
    vleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdhigsidpncnvsevvk
    daydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratve
    shesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymystgfgyglpisrly
    akyfqgdlqlfsmegfgtdaviylkalstdsverlpv