PDB entry 5j6a
View 5j6a on RCSB PDB site
Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS46
Class: Transferase/Transferase Inhibitor
Keywords: GHKL protein kinase, pyruvate dehydrogenase complex, Mitochondrial protein kinases, Impaired glucose oxidation, Hepatic steatosis, Type 2 diabetes, Cancer, Bergerat nucleotide-binding fold, protein kinase, Transferase-Transferase Inhibitor complex
Deposited on
2016-04-04, released
2017-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-25, with a file datestamp of
2019-12-20.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: PDK2, PDHK2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5j6aa1, d5j6aa2 - Heterogens: P46, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5j6aA (A:)
sknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimke
inllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvv
ptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkh
igsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyh
mlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsym
ystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstds
verlpvynksawrhyqtiqeagdwcvpstepkntstyrvs
Sequence, based on observed residues (ATOM records): (download)
>5j6aA (A:)
aslagapkyiehfskfspsplsmkqfldfgscektsftflrqelpvrlanimkeinllpd
rvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqg
vleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdhigsidpncnvsevvk
daydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratve
shesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymystgfgyglpisrly
akyfqgdlqlfsmegfgtdaviylkalstdsverlpv