PDB entry 5j5a

View 5j5a on RCSB PDB site
Description: Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 70786556)
Class: Ligase/Ligase Inhibitor
Keywords: synthetase, ligase, methionine, inhibitor, Ligase-Ligase Inhibitor complex
Deposited on 2016-04-01, released 2017-01-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-01-25, with a file datestamp of 2017-01-20.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Methionyl-tRNA synthetase, putative
    Species: Trypanosoma brucei brucei [TaxId:185431]
    Gene: Tb10.70.6470
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q38C91
      • engineered mutation (77)
      • engineered mutation (220-222)
      • engineered mutation (267)
      • engineered mutation (271)
    Domains in SCOPe 2.07: d5j5aa1, d5j5aa2
  • Chain 'B':
    Compound: Methionyl-tRNA synthetase, putative
    Species: Trypanosoma brucei brucei [TaxId:185431]
    Gene: Tb10.70.6470
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q38C91 (5-End)
      • expression tag (0-4)
      • engineered mutation (77)
      • engineered mutation (220-222)
      • engineered mutation (267)
      • engineered mutation (271)
    Domains in SCOPe 2.07: d5j5ab1, d5j5ab2, d5j5ab3
  • Heterogens: MET, 756, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5j5aA (A:)
    gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
    kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
    gdiylgryegwysisdesfltpqnitdgvdkdgnpckvslesghvvtwvseenymfrlsa
    frerllewyhanpgcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcv
    yvwldaltnyltgsrlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafl
    lsaglplpkkivahgwwtkdrkkiskslgnvfdpvekaeefgydalkyfllresgfsddg
    dysdknmiarlngeladtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgt
    adhyylipdiqkaiiavfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttl
    llspilprksvvifdmlgvpevhrkgienfefgavppgtrlgpavegevlfskrstentk
    st
    

    Sequence, based on observed residues (ATOM records): (download)
    >5j5aA (A:)
    vekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgqkvaeaa
    kqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqkgdiylg
    ryegwysisdesfltpqnitdgvdkdgnpckvslesghvvtwvseenymfrlsafrerll
    ewyhanpgcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcvyvwlda
    ltnyltgsrlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafllsaglp
    lpkkivahgwwtknvfdpvekaeefgydalkyfllresgfsddgdysdknmiarlngela
    dtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgtadhyylipdiqkaiia
    vfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttlllspilprksvvifdm
    lgvpevhrkgienfefgavppgtrlgpavevlfskrst
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5j5aB (B:)
    gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
    kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
    gdiylgryegwysisdesfltpqnitdgvdkdgnpckvslesghvvtwvseenymfrlsa
    frerllewyhanpgcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcv
    yvwldaltnyltgsrlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafl
    lsaglplpkkivahgwwtkdrkkiskslgnvfdpvekaeefgydalkyfllresgfsddg
    dysdknmiarlngeladtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgt
    adhyylipdiqkaiiavfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttl
    llspilprksvvifdmlgvpevhrkgienfefgavppgtrlgpavegevlfskrstentk
    st
    

    Sequence, based on observed residues (ATOM records): (download)
    >5j5aB (B:)
    gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
    kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
    gdiylgryegwysisdefltpqnkvslesghvvtwvseenymfrlsafrerllewyhanp
    gcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcvyvwldaltnyltg
    srlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafllsaglplpkkiva
    hgwwtkdrkkiskslgnvfdpvekaeefgydalkyfllresgfsddgdysdknmiarlng
    eladtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgtadhyylipdiqka
    iiavfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttlllspilprksvvi
    fdmlgvpevhrkgienfefgavppgtrlgpavegevlfskrst