PDB entry 5ita
View 5ita on RCSB PDB site
Description: Crystal Structure of BRAF Kinase Domain Bound to AZ-VEM
Class: transferase/transferase inhibitor
Keywords: transferase, kinase and inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2016-03-16, released
2016-08-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2016-08-10, with a file datestamp of
2016-08-05.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Serine/threonine-protein kinase B-raf
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
- Uniprot P15056 (21-End)
- engineered mutation (116-117)
- engineered mutation (124)
- engineered mutation (135)
- engineered mutation (161)
- engineered mutation (240)
- engineered mutation (246)
- engineered mutation (261)
- engineered mutation (279)
- engineered mutation (282)
- engineered mutation (286)
- engineered mutation (289)
Domains in SCOPe 2.08: d5itaa_ - Chain 'B':
Compound: Serine/threonine-protein kinase B-raf
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
- Uniprot P15056 (21-End)
- engineered mutation (116-117)
- engineered mutation (124)
- engineered mutation (135)
- engineered mutation (161)
- engineered mutation (203)
- engineered mutation (240)
- engineered mutation (246)
- engineered mutation (261)
- engineered mutation (279)
- engineered mutation (282)
- engineered mutation (286)
- engineered mutation (289)
- engineered mutation (293)
Domains in SCOPe 2.08: d5itab_ - Heterogens: 6DC, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5itaA (A:)
mgsshhhhhhssglvprgshmddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmln
vtaptpqqlqafknevgvlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhaset
kfemkklidiarqtargmdylhaksiihrdlksnniflhedntvkigdfglatvksrwsg
shqfeqlsgsilwmapevirmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqii
emvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfprilaeieelarelsg
Sequence, based on observed residues (ATOM records): (download)
>5itaA (A:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfglsilwmapevirmnpysfqsdvyafgivlye
lmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfp
rilaeieela
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5itaB (B:)
mgsshhhhhhssglvprgshmddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmln
vtaptpqqlqafknevgvlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhaset
kfemkklidiarqtargmdylhaksiihrdlksnniflhedntvkigdfglatvksrwsg
shqfeqlsgsilwmapevirmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqii
emvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfprilaeieelarelsg
Sequence, based on observed residues (ATOM records): (download)
>5itaB (B:)
ddweipdgqitvgqrigsgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhak
siihrdlksnniflhedntvkigdfsgsilwmapevirmqsnpysfqsdvyafgivlyel
mtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfpr
ilaeieelarel