PDB entry 5ist
View 5ist on RCSB PDB site
Description: Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
Class: oxidoreductase
Keywords: Oxidoreductase, Dihydrofolate Reductase, NADPH, Zwitterion, Antibiotics
Deposited on
2016-03-15, released
2017-06-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-11, with a file datestamp of
2019-12-06.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: N/A
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'X':
Compound: dihydrofolate reductase
Species: Staphylococcus aureus [TaxId:1280]
Gene: folA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5istx_ - Heterogens: U06, XNP, NAP, HOH
PDB Chain Sequences:
- Chain 'X':
Sequence, based on SEQRES records: (download)
>5istX (X:)
tlsilvahdlqrvigfenqlpwhlpndlknvkklstghtlvmgrktfesigkplpnrrnv
vltsdtsfnvegvdvihsiediyqlpghvfifggqtlfeemidkvddmyitviegkfrgd
tffppytfedwevassvegkldekntiphtflhlirkleh
Sequence, based on observed residues (ATOM records): (download)
>5istX (X:)
tlsilvahdlqrvigfenqlpwhlpndlknvkklstghtlvmgrktfesigkplpnrrnv
vltsdtsfnvegvdvihsiediyqlpghvfifggqtlfeemidkvddmyitviegkfrgd
tffppytfedwevassvegkldekntiphtflhlirk