PDB entry 5is8

View 5is8 on RCSB PDB site
Description: Crystal structure of mouse CARM1 in complex with inhibitor SA0271
Class: transferase
Keywords: protein arginine methyltransferase, catalytic domain, chromatin regulator, mRNA processing, mRNA splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Deposited on 2016-03-15, released 2017-03-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-15, with a file datestamp of 2017-03-10.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5is8b_
  • Chain 'C':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5is8d_
  • Heterogens: 6D1, EDO, SAH, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5is8B (B:)
ghmghtlersvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkd
kivldvgcgsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveev
slpeqvdiiisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlyme
qftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakeg
dlhrieipfkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsp
lfakagdtlsgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgttpsppp
gshytspsenmwntgstynls

    Sequence, based on observed residues (ATOM records): (download) 
    >5is8B (B:)
avqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqa
garkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfn
ermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsa
lrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvh
glafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankr
qsydisivaqvdqtgskssnlldlknpffryt

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5is8D (D:)
ghmghtlersvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkd
kivldvgcgsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveev
slpeqvdiiisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlyme
qftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakeg
dlhrieipfkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsp
lfakagdtlsgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgttpsppp
gshytspsenmwntgstynls

    Sequence, based on observed residues (ATOM records): (download) 
    >5is8D (D:)
vqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqag
arkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfne
rmlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsal
rgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvhg
lafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankrq
sydisivaqvdqtgskssnlldlknpffry