PDB entry 5irc

View 5irc on RCSB PDB site
Description: p190A GAP domain complex with RhoA
Class: protein binding
Keywords: protein-protein complex, transition state, GTPase, GAP domain, protein binding
Deposited on 2016-03-12, released 2016-08-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho GTPase-activating protein 35
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Arhgap35, Grlf1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P81128 (3-200)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d5irca1, d5irca2
  • Chain 'B':
    Compound: Rho GTPase-activating protein 35
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Arhgap35, Grlf1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ircb_
  • Chain 'D':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (Start-185)
      • engineered mutation (29)
    Domains in SCOPe 2.08: d5ircd_
  • Chain 'F':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586
      • engineered mutation (29)
    Domains in SCOPe 2.08: d5ircf_
  • Heterogens: CL, GDP, MG, MGF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5ircA (A:)
agswesnyfgvplttvvtpekpipifiercieyieatglstegiyrvsgnksemeslqrq
fdqdhnldlaekdftvntvagamksffselpdplvpysmqidlveahkindreqklhalk
evlkkfpkenhevfkyvishlnrvshnnkvnlmtsenlsicfwptlmrpdfssmdaltat
rsyqtiielfiqqcpfffynr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ircB (B:)
agswesnyfgvplttvvtpekpipifiercieyieatglstegiyrvsgnksemeslqrq
fdqdhnldlaekdftvntvagamksffselpdplvpysmqidlveahkindreqklhalk
evlkkfpkenhevfkyvishlnrvshnnkvnlmtsenlsicfwptlmrpdfssmdaltat
rsyqtiielfiqqcpfffynr

    Sequence, based on observed residues (ATOM records): (download) 
    >5ircB (B:)
esnyfgvplttvvtpekpipifiercieyieatglstegiyrvsgnksemeslqrqfdqd
hnldlaekdftvntvagamksffselpdplvpysmqidlveahkindreqklhalkevlk
kfpkenhevfkyvishlnrvshnnkvnlmtsenlsicfwptlmrpdfssmdaltatrsyq
tiielfiqqcpfffyn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5ircD (D:)
gamgspaairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvel
alwdtagqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilv
gnkkdlrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfemat
raalqa

    Sequence, based on observed residues (ATOM records): (download) 
    >5ircD (D:)
irkklvivgdgacgktcllivnvyvptvfenyvadievdgkqvelalwdtagqedydrlr
plsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndehtrre
lakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5ircF (F:)
gamgspaairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvel
alwdtagqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilv
gnkkdlrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfemat
raalqa

    Sequence, based on observed residues (ATOM records): (download) 
    >5ircF (F:)
irkklvivgdgacgktcllivnvyvptvfenyvadievdgkqvelalwdtagqedydrlr
plsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndehtrre
lakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq