PDB entry 5ipz

View 5ipz on RCSB PDB site
Description: Crystal structure of human carbonic anhydrase isozyme IV with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide
Class: lyase
Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
Deposited on 2016-03-10, released 2017-03-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-07-11, with a file datestamp of 2018-07-06.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ipza_
  • Chain 'B':
    Compound: Carbonic anhydrase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ipzb_
  • Chain 'C':
    Compound: Carbonic anhydrase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ipzc_
  • Chain 'D':
    Compound: Carbonic anhydrase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CA4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ipzd_
  • Heterogens: ZN, 6CC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ipzA (A:)
maeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydk
kqtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfam
emhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemst
tmaesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqkly
ydkeqtvsmkdnvrplqqlgqrtviks

    Sequence, based on observed residues (ATOM records): (download) 
    >5ipzA (A:)
eshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkq
twtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamem
hivhekekgtsrnvdpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaess
lldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqt
vsmkdnvrplqqlgqrtviks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ipzB (B:)
maeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydk
kqtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfam
emhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemst
tmaesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqkly
ydkeqtvsmkdnvrplqqlgqrtviks

    Sequence, based on observed residues (ATOM records): (download) 
    >5ipzB (B:)
eshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkq
twtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamem
hivhekekgdpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldll
pkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkd
nvrplqqlgqrtviks

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5ipzC (C:)
maeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydk
kqtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfam
emhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemst
tmaesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqkly
ydkeqtvsmkdnvrplqqlgqrtviks

    Sequence, based on observed residues (ATOM records): (download) 
    >5ipzC (C:)
eshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkq
twtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamem
hivhekekgpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldllp
keeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkdn
vrplqqlgqrtviks

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5ipzD (D:)
maeshwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydk
kqtwtvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfam
emhivhekekgtsrnvkeaqdpedeiavlaflveagtqvnegfqplvealsnipkpemst
tmaesslldllpkeeklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqkly
ydkeqtvsmkdnvrplqqlgqrtviks

    Sequence, based on observed residues (ATOM records): (download) 
    >5ipzD (D:)
hwcyevqaessnypclvpvkwggncqkdrqspinivttkakvdkklgrfffsgydkkqtw
tvqnnghsvmmllenkasisggglpapyqakqlhlhwsdlpykgsehsldgehfamemhi
vhekekgpedeiavlaflveagtqvnegfqplvealsnipkpemsttmaesslldllpke
eklrhyfrylgslttptcdekvvwtvfrepiqlhreqilafsqklyydkeqtvsmkdnvr
plqqlgqrtviks