PDB entry 5inf

View 5inf on RCSB PDB site
Description: Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics
Class: transferase
Keywords: Polyketide, Crotonase, Extender-Unit, Acyl-CoA, TRANSFERASE
Deposited on 2016-03-07, released 2016-12-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-12-28, with a file datestamp of 2016-12-22.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carboxyl transferase
    Species: Streptomyces ambofaciens ATCC 23877 [TaxId:278992]
    Gene: SAM23877_7108, SAMR0483
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5infa1, d5infa2
  • Chain 'B':
    Compound: Carboxyl transferase
    Species: Streptomyces ambofaciens ATCC 23877 [TaxId:278992]
    Gene: SAM23877_7108, SAMR0483
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5infb1, d5infb2
  • Chain 'C':
    Compound: Carboxyl transferase
    Species: Streptomyces ambofaciens ATCC 23877 [TaxId:278992]
    Gene: SAM23877_7108, SAMR0483
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5infc1, d5infc2
  • Chain 'D':
    Compound: Carboxyl transferase
    Species: Streptomyces ambofaciens ATCC 23877 [TaxId:278992]
    Gene: SAM23877_7108, SAMR0483
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5infd1, d5infd2
  • Chain 'E':
    Compound: Carboxyl transferase
    Species: Streptomyces ambofaciens ATCC 23877 [TaxId:278992]
    Gene: SAM23877_7108, SAMR0483
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5infe1, d5infe2
  • Chain 'F':
    Compound: Carboxyl transferase
    Species: Streptomyces ambofaciens ATCC 23877 [TaxId:278992]
    Gene: SAM23877_7108, SAMR0483
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5inff1, d5inff2
  • Heterogens: HXC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5infA (A:)
gidpftmslqepvspveesptstadriadlaarheeavvlaekkaadrqhlkgkltarar
idllldpgsfveldefvrhrtveagiprpygdgvvtghgtidgrqvcvfshdfttlggsm
geafgskvvkiydfamsvgcpvigindsggariqegvmsiayytelgvrnvhssgvipqi
slimgpcaggsvyspaltdftvmvkdisymfvtgpevvsavmgeqvtaeqlggpavhaev
sgnahyvgddeqdaiswvqtllgylppnnldpapvydhdcapgiteadlaldtvipdseq
qvydmadvitavlddgdyleihpdfarniicalgrveghsvavvanqprhlagvldidas
ekaarfirfcdsfnipvltfmdvpgylpgvgqehqgiirrgiklfyayaestvpkitvit
rkaygggyavmgsrqigadrvmawptaeiavmgansavpilhrrelaavppeeraavken
lvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

    Sequence, based on observed residues (ATOM records): (download) 
    >5infA (A:)
tstadriadlaarheeavvlaekkaadrqhlkgkltararidllldpgsfveldefvrhr
tprpygdgvvtghgtidgrqvcvfshdfttlggsmgeafgskvvkiydfamsvgcpvigi
ndsggariqegvmsiayytelgvrnvhssgvipqislimgpcaggsvyspaltdftvmvk
disymfvtgpevvvtaeqlggpavhaevsgnahyvgddeqdaiswvqtllgylppnnldp
apvydhdcapgiteadlaldtvipdseqqvydmadvitavlddgdyleihpdfarniica
lgrveghsvavvanqprhlagvldidasekaarfirfcdsfnipvltfmdvpgylpgvgq
ehqgiirrgiklfyayaestvpkitvitrkaygggyavmgsrqigadrvmawptaeiavm
gansarrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5infB (B:)
gidpftmslqepvspveesptstadriadlaarheeavvlaekkaadrqhlkgkltarar
idllldpgsfveldefvrhrtveagiprpygdgvvtghgtidgrqvcvfshdfttlggsm
geafgskvvkiydfamsvgcpvigindsggariqegvmsiayytelgvrnvhssgvipqi
slimgpcaggsvyspaltdftvmvkdisymfvtgpevvsavmgeqvtaeqlggpavhaev
sgnahyvgddeqdaiswvqtllgylppnnldpapvydhdcapgiteadlaldtvipdseq
qvydmadvitavlddgdyleihpdfarniicalgrveghsvavvanqprhlagvldidas
ekaarfirfcdsfnipvltfmdvpgylpgvgqehqgiirrgiklfyayaestvpkitvit
rkaygggyavmgsrqigadrvmawptaeiavmgansavpilhrrelaavppeeraavken
lvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

    Sequence, based on observed residues (ATOM records): (download) 
    >5infB (B:)
tstadriadlaarheeavvlaekkaadrqhlkgkltararidllldpgsfveldefvrhr
tprpygdgvvtghgtidgrqvcvfshdfttlggsmgeafgskvvkiydfamsvgcpvigi
ndsggariqegvmsiayytelgvrnvhssgvipqislimgpcaggsvyspaltdftvmvk
disymfvtgpevvsavmgeqvtaeqlggpavhaevsgnahyvgddeqdaiswvqtllgyl
ppnnldpapvydhdcapgiteadlaldtvipdseqqvydmadvitavlddgdyleihpdf
arniicalgrveghsvavvanqprhlagvldidasekaarfirfcdsfnipvltfmdvpg
ylpgvgqehqgiirrgiklfyayaestvpkitvitrkaygggyavmgsrqigadrvmawp
taeiavmgarfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5infC (C:)
gidpftmslqepvspveesptstadriadlaarheeavvlaekkaadrqhlkgkltarar
idllldpgsfveldefvrhrtveagiprpygdgvvtghgtidgrqvcvfshdfttlggsm
geafgskvvkiydfamsvgcpvigindsggariqegvmsiayytelgvrnvhssgvipqi
slimgpcaggsvyspaltdftvmvkdisymfvtgpevvsavmgeqvtaeqlggpavhaev
sgnahyvgddeqdaiswvqtllgylppnnldpapvydhdcapgiteadlaldtvipdseq
qvydmadvitavlddgdyleihpdfarniicalgrveghsvavvanqprhlagvldidas
ekaarfirfcdsfnipvltfmdvpgylpgvgqehqgiirrgiklfyayaestvpkitvit
rkaygggyavmgsrqigadrvmawptaeiavmgansavpilhrrelaavppeeraavken
lvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

    Sequence, based on observed residues (ATOM records): (download) 
    >5infC (C:)
ptstadriadlaarheeavvlaekkaadrqhlkgkltararidllldpgsfveldefvrh
rtprpygdgvvtghgtidgrqvcvfshdfttlggsmgeafgskvvkiydfamsvgcpvig
indsggariqegvmsiayytelgvrnvhssgvipqislimgpcaggsvyspaltdftvmv
kdisymfvtgpevvsavmgeqvtaeqlggpavhaevsgnahyvgddeqdaiswvqtllgy
lppnnldpapvydhdcapgiteadlaldtvipdseqqvydmadvitavlddgdyleihpd
farniicalgrveghsvavvanqprhlagvldidasekaarfirfcdsfnipvltfmdvp
gylpgvgqehqgiirrgiklfyayaestvpkitvitrkaygggyavmgsrqigadrvmaw
ptaeiavmgansarrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarpark
hgnipl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5infD (D:)
gidpftmslqepvspveesptstadriadlaarheeavvlaekkaadrqhlkgkltarar
idllldpgsfveldefvrhrtveagiprpygdgvvtghgtidgrqvcvfshdfttlggsm
geafgskvvkiydfamsvgcpvigindsggariqegvmsiayytelgvrnvhssgvipqi
slimgpcaggsvyspaltdftvmvkdisymfvtgpevvsavmgeqvtaeqlggpavhaev
sgnahyvgddeqdaiswvqtllgylppnnldpapvydhdcapgiteadlaldtvipdseq
qvydmadvitavlddgdyleihpdfarniicalgrveghsvavvanqprhlagvldidas
ekaarfirfcdsfnipvltfmdvpgylpgvgqehqgiirrgiklfyayaestvpkitvit
rkaygggyavmgsrqigadrvmawptaeiavmgansavpilhrrelaavppeeraavken
lvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

    Sequence, based on observed residues (ATOM records): (download) 
    >5infD (D:)
tstadriadlaarheeavvlaekkaadrqhlkgkltararidllldpgsfveldefvrhr
tiprpygdgvvtghgtidgrqvcvfshdfttlggsmgeafgskvvkiydfamsvgcpvig
indsggariqegvmsiayytelgvrnvhssgvipqislimgpcaggsvyspaltdftvmv
kdisymfvtgpevvsaqvtaeqlggpavhaevsgnahyvgddeqdaiswvqtllgylppn
nldpapvydhdcapgiteadlaldtvipdseqqvydmadvitavlddgdyleihpdfarn
iicalgrveghsvavvanqprhlagvldidasekaarfirfcdsfnipvltfmdvpgylp
gvgqehqgiirrgiklfyayaestvpkitvitrkaygggyavmgsrqigadrvmawptae
iavmgarrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5infE (E:)
gidpftmslqepvspveesptstadriadlaarheeavvlaekkaadrqhlkgkltarar
idllldpgsfveldefvrhrtveagiprpygdgvvtghgtidgrqvcvfshdfttlggsm
geafgskvvkiydfamsvgcpvigindsggariqegvmsiayytelgvrnvhssgvipqi
slimgpcaggsvyspaltdftvmvkdisymfvtgpevvsavmgeqvtaeqlggpavhaev
sgnahyvgddeqdaiswvqtllgylppnnldpapvydhdcapgiteadlaldtvipdseq
qvydmadvitavlddgdyleihpdfarniicalgrveghsvavvanqprhlagvldidas
ekaarfirfcdsfnipvltfmdvpgylpgvgqehqgiirrgiklfyayaestvpkitvit
rkaygggyavmgsrqigadrvmawptaeiavmgansavpilhrrelaavppeeraavken
lvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

    Sequence, based on observed residues (ATOM records): (download) 
    >5infE (E:)
stadriadlaarheeavvlaekkaadrqhlkgkltararidllldpgsfveldefvrhrt
vprpygdgvvtghgtidgrqvcvfshdfttlggsmgeafgskvvkiydfamsvgcpvigi
ndsggariqegvmsiayytelgvrnvhssgvipqislimgpcaggsvyspaltdftvmvk
disymfvtgpevvgeqvtaeqlggpavhaevsgnahyvgddeqdaiswvqtllgylppnn
ldpapvydhdcapgiteadlaldtvipdseqqvydmadvitavlddgdyleihpdfarni
icalgrveghsvavvanqprhlagvldidasekaarfirfcdsfnipvltfmdvpgylpg
vgqehqgiirrgiklfyayaestvpkitvitrkaygggyavmgsrqigadrvmawptaei
avmgansavrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnip
l

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5infF (F:)
gidpftmslqepvspveesptstadriadlaarheeavvlaekkaadrqhlkgkltarar
idllldpgsfveldefvrhrtveagiprpygdgvvtghgtidgrqvcvfshdfttlggsm
geafgskvvkiydfamsvgcpvigindsggariqegvmsiayytelgvrnvhssgvipqi
slimgpcaggsvyspaltdftvmvkdisymfvtgpevvsavmgeqvtaeqlggpavhaev
sgnahyvgddeqdaiswvqtllgylppnnldpapvydhdcapgiteadlaldtvipdseq
qvydmadvitavlddgdyleihpdfarniicalgrveghsvavvanqprhlagvldidas
ekaarfirfcdsfnipvltfmdvpgylpgvgqehqgiirrgiklfyayaestvpkitvit
rkaygggyavmgsrqigadrvmawptaeiavmgansavpilhrrelaavppeeraavken
lvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnkrqarparkhgnipl

    Sequence, based on observed residues (ATOM records): (download) 
    >5infF (F:)
stadriadlaarheeavvlaekkaadrqhlkgkltararidllldpgsfveldefvrhrp
rpygdgvvtghgtidgrqvcvfshdfttlggsmgeafgskvvkiydfamsvgcpvigind
sggariqegvmsiayytelgvrnvhssgvipqislimgpcaggsvyspaltdftvmvkdi
symfvtgpevvsavmgeqvtaeqlggpavhaevsgnahyvgddeqdaiswvqtllgylpp
nnldpapvydhdcapgiteadlaldtvipdseqqvydmadvitavlddgdyleihpdfar
niicalgrveghsvavvanqprhlagvldidasekaarfirfcdsfnipvltfmdvpgyl
pgvgqehqgiirrgiklfyayaestvpkitvitrkaygggyavmgsrqigadrvmawpta
eiavmgansavpilhnlvddyrrrfgnpyeaaahgyvdmvispsrtryevaralaslrnk
rqarparkhgnipl