PDB entry 5ibs

View 5ibs on RCSB PDB site
Description: Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Class: hydrolase
Keywords: TYROSINE PHOSPHATASE SHP2, Tyrosine-protein phosphatase non-receptor type 11, HYDROLASE
Deposited on 2016-02-22, released 2016-04-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-05-04, with a file datestamp of 2016-04-29.
Experiment type: XRAY
Resolution: 2.32 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-525)
      • engineered mutation (76)
    Domains in SCOPe 2.07: d5ibsa1, d5ibsa2, d5ibsa3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-525)
      • engineered mutation (76)
    Domains in SCOPe 2.07: d5ibsb1, d5ibsb2, d5ibsb3
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ibsA (A:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaqlvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ibsA (A:)
    rrwfhpnitgveaenllltrgvdgsflarppgdftlsvrrngavthikiqntgdyydlyg
    gekfatlaqlvqyymehgqlkevielkyplncadptserwfhghlsgkeaeklltekgkh
    gsflvresqshpgdfvlsvrtgdkskvthvmircqelkydvgggerfdsltdlvehykkn
    pmvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkegqr
    qenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpekksyiatqgclqntvnd
    fwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlre
    lklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcs
    agigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqh
    yietl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5ibsB (B:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaqlvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ibsB (B:)
    rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
    dlyggekfatlaqlvqyymehhgqlielkyplncadptserwfhghlsgkeaeklltekg
    khgsflvrhpgdfvlsvrtgkvthvmircqelkydvgggerfdsltdlvehykknpmvet
    lgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenkn
    knryknilpfdhtrvvlhdgdpepvsdyinaniimpekksyiatqgclqntvndfwrmvf
    qensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskv
    gqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrt
    gtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl