PDB entry 5i76

View 5i76 on RCSB PDB site
Description: Crystal structure of FM318, a recombinant Fab adopted from cetuximab
Class: immune system
Keywords: Antibody fragment, Recombinant Fab, Cetuximab, EGFR, IMMUNE SYSTEM
Deposited on 2016-02-16, released 2016-12-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: FM318_light_chain
    Species: Homo sapiens/Mus musculus xenograft [TaxId:1383439]
    Database cross-references and differences (RAF-indexed):
    • PDB 5I76 (0-End)
    Domains in SCOPe 2.08: d5i76a1, d5i76a2
  • Chain 'B':
    Compound: FM318_heavy_cahin
    Species: Homo sapiens/Mus musculus xenograft [TaxId:1383439]
    Database cross-references and differences (RAF-indexed):
    • PDB 5I76 (0-End)
    Domains in SCOPe 2.08: d5i76b_
  • Chain 'C':
    Compound: FM318_light_chain
    Species: Homo sapiens/Mus musculus xenograft [TaxId:1383439]
    Database cross-references and differences (RAF-indexed):
    • PDB 5I76 (0-End)
    Domains in SCOPe 2.08: d5i76c1, d5i76c2
  • Chain 'D':
    Compound: FM318_heavy_cahin
    Species: Homo sapiens/Mus musculus xenograft [TaxId:1383439]
    Database cross-references and differences (RAF-indexed):
    • PDB 5I76 (0-End)
    Domains in SCOPe 2.08: d5i76d_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5i76A (A:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgaec

    Sequence, based on observed residues (ATOM records): (download) 
    >5i76A (A:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrga

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5i76B (B:)
qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyn
tpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsaa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records): (download) 
    >5i76B (B:)
qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyn
tpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsaa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5i76C (C:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgaec

    Sequence, based on observed residues (ATOM records): (download) 
    >5i76C (C:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrga

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5i76D (D:)
qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyn
tpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsaa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdk

    Sequence, based on observed residues (ATOM records): (download) 
    >5i76D (D:)
qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyn
tpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsaa
stkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks