PDB entry 5i6v

View 5i6v on RCSB PDB site
Description: Structure of F285S, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Class: hydrolase
Keywords: SHP2, Cancer-Associated Mutation, Inhibitors, HYDROLASE
Deposited on 2016-02-16, released 2016-04-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-05-04, with a file datestamp of 2016-04-29.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-524)
      • engineered mutation (284)
    Domains in SCOPe 2.07: d5i6va1, d5i6va2, d5i6va3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-524)
      • engineered mutation (284)
    Domains in SCOPe 2.07: d5i6vb1, d5i6vb2, d5i6vb3
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5i6vA (A:)
    mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
    dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
    eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
    vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
    dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpsdhtrvvlhdgdpnep
    vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
    ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
    rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
    ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5i6vA (A:)
    srrwfhpnitgveaenllltrgvdgsflarpspgdftlsvrrngavthikiqntgdyydl
    yggekfatlaelvqyymehhgqlkevielkyplncadptserwfhghlsgkeaeklltek
    gkhgsflvresqshpgdfvlsvrtgdkskvthvmircqelkydvgggerfdsltdlvehy
    kknpmvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrke
    gqrqenknknryknilpsdhtrvvlhdgdpnepvsdyinaniimpekksyiatqgclqnt
    vndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdyt
    lrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvv
    hcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiyma
    vqhyietl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5i6vB (B:)
    mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
    dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
    eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
    vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
    dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpsdhtrvvlhdgdpnep
    vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
    ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
    rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
    ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5i6vB (B:)
    tsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgd
    yydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgke
    aeklltekgkhgsflvresqshpgdfvlsvrtgkskvthvmircqelkydvgggerfdsl
    tdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeck
    llysrkegqrqenknknryknilpsdhtrvvlhdgdpnepvsdyinaniimpepkksyia
    tqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvk
    esaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesi
    mdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqtea
    qyrfiymavqhyietl