PDB entry 5i4o
View 5i4o on RCSB PDB site
Description: Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate zinc-chelator water-soluble inhibitor (DC28).
Class: hydrolase
Keywords: Inhibitor, complex, glycoconjugate, metalloprotease, hydrolase
Deposited on
2016-02-12, released
2016-07-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-01-24, with a file datestamp of
2018-01-19.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (Start-158)
- conflict (66)
- conflict (114)
Domains in SCOPe 2.08: d5i4oa_ - Chain 'B':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (Start-158)
- conflict (66)
- conflict (114)
Domains in SCOPe 2.08: d5i4ob_ - Chain 'C':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (Start-158)
- conflict (66)
- conflict (114)
Domains in SCOPe 2.08: d5i4oc_ - Chain 'D':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (Start-158)
- conflict (66)
- conflict (114)
Domains in SCOPe 2.08: d5i4od_ - Heterogens: V28, ZN, CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5i4oA (A:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i4oA (A:)
vwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfarga
hgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslglg
hssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5i4oB (B:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i4oB (B:)
vwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfarga
hgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslglg
hssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5i4oC (C:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i4oC (C:)
vwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfarga
hgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslglg
hssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5i4oD (D:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i4oD (D:)
vwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfarga
hgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslglg
hssdpkavmfptykyvdintfrlsaddirgiqslyg