PDB entry 5i4n

View 5i4n on RCSB PDB site
Description: Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP
Class: transferase
Keywords: transferase, pseudokinase, ATP binding
Deposited on 2016-02-12, released 2016-04-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-06-08, with a file datestamp of 2016-06-03.
Experiment type: XRAY
Resolution: 1.54 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (61)
      • engineered mutation (82)
      • engineered mutation (124)
      • engineered mutation (242)
      • engineered mutation (259)
      • expression tag (284-285)
    Domains in SCOPe 2.08: d5i4na1, d5i4na2
  • Heterogens: ATP, MG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5i4nA (A:)
mvfhkirnedlifneslgqgtftkifkgvrrevgdygqlhetevllkvldkahrnysesf
faaasmmsklshkhlvlnygvcfcgdenilvqefvkfgsldtylkknkncinilwkleva
kqlaaamhfleentlihgnvcaknillireedrktgnppfiklsdpgisitvlpkdilqe
ripwvppecienpknlnlatdkwsfgttlweicsggdkplsaldsqrklqfyedrhqlpa
pkaaelanlinncmdyepdhrpsfraiirdlnslftpdlvprgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5i4nA (A:)
fhkirnedlifneslgqgtftkifkgvrrevgdygqlhetevllkvldkahrnysesffa
aasmmsklshkhlvlnygvcfcgdenilvqefvkfgsldtylkknkncinilwklevakq
laaamhfleentlihgnvcaknillireedrktgnppfiklsdpgisitvlpkdilqeri
pwvppecienpknlnlatdkwsfgttlweicsggdkplsaldsqrklqfyedrhqlpapk
aaelanlinncmdyepdhrpsfraiirdlnslfhh