PDB entry 5i43
View 5i43 on RCSB PDB site
Description: Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelator water-soluble inhibitor (DC32).
Class: hydrolase
Keywords: Inhibitor, complex, glycoconjugate, metalloprotease, hydrolase
Deposited on
2016-02-11, released
2016-07-06
The last revision prior to the SCOPe 2.07 freeze date was dated
2016-08-17, with a file datestamp of
2016-08-12.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (Start-158)
- engineered mutation (66)
- engineered mutation (114)
Domains in SCOPe 2.07: d5i43a_ - Chain 'B':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- initiating methionine (0)
- engineered mutation (66)
- engineered mutation (114)
Domains in SCOPe 2.07: d5i43b_ - Chain 'C':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- engineered mutation (66)
- engineered mutation (114)
Domains in SCOPe 2.07: d5i43c_ - Chain 'D':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: MMP12, HME
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- engineered mutation (66)
- engineered mutation (114)
Domains in SCOPe 2.07: d5i43d_ - Heterogens: ZN, CA, 67M, EDO, DMS, PGO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5i43A (A:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i43A (A:)
pvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfarg
ahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslgl
ghssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>5i43B (B:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5i43C (C:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i43C (C:)
gpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfar
gahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslg
lghssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5i43D (D:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>5i43D (D:)
gpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfar
gahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhqighslg
lghssdpkavmfptykyvdintfrlsaddirgiqslyg