PDB entry 5i2k

View 5i2k on RCSB PDB site
Description: Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19)
Class: transport protein
Keywords: GluN1, GluN2A, receptor, NMDA, TRANSPORT PROTEIN
Deposited on 2016-02-09, released 2016-03-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-04-06, with a file datestamp of 2016-04-01.
Experiment type: XRAY
Resolution: 2.86 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: GRIN2A, NMDAR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12879 (Start-140)
      • linker (141-142)
    • Uniprot Q12879 (143-End)
    Domains in SCOPe 2.08: d5i2ka_
  • Chain 'B':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05586 (2-152)
      • linker (153-154)
    • Uniprot Q05586 (155-End)
    Domains in SCOPe 2.08: d5i2kb_
  • Heterogens: GLU, GLY, 67H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5i2kA (A:)
gspddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvkkcckg
fcidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgsltineer
sevvdfsvpfvetgisvmvsrgtqvtglsdkkfqrphdysppfrfgtvpngsternirnn
ypymhqymtkfnqkgvedalvslktgkldafiydaavlnykagrdegcklvtigsgyifa
ttgygialqkgspwkrqidlallqfvgdgemeeletlwltgichn

    Sequence, based on observed residues (ATOM records): (download) 
    >5i2kA (A:)
nhlsivtleeapfvivedidpetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilk
klsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfs
vpfvetgisvmvsrgtqvtglsdkkfqrphdysppfrfgtvpngsternirnnypymhqy
mtkfnqkgvedalvslktgkldafiydaavlnykagrdegcklvtigsgyifattgygia
lqkgspwkrqidlallqfvgdgemeeletlwltgic

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5i2kB (B:)
gsmstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtspgsprhtv
pqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmgellsgqad
mivapltinneraqyiefskpfkyqgltilvkkgtritgindprlrnpsdkfiyatvkqs
svdiyfrrqvelstmyrhmekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlv
ttgelffrsgfgigmrkdspwkqnvslsilkshengfmedldktwvryqecds

    Sequence, based on observed residues (ATOM records): (download) 
    >5i2kB (B:)
mstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtspgsprhtvpq
ccygfcidlliklartmnftyevhlvadgkfgtqervnkkewngmmgellsgqadmivap
ltinneraqyiefskpfkyqgltilvkkgtritgindprlrnpsdkfiyatvkqssvdiy
frrqvelstmyrhmekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgel
ffrsgfgigmrkdspwkqnvslsilkshengfmedldktwvryqec