PDB entry 5i2e

View 5i2e on RCSB PDB site
Description: Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine
Class: hydrolase/hydrolase inhibitor
Keywords: HINT, histidine triad, HIT, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2016-02-08, released 2016-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-09-07, with a file datestamp of 2016-09-02.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5i2ea_
  • Chain 'B':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5i2eb_
  • Heterogens: 67D, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5i2eA (A:)
snamadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipk
khisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlhvlg
grqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >5i2eA (A:)
rpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaeddde
sllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlhvlggrqmhwppg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5i2eB (B:)
snamadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipk
khisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlhvlg
grqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >5i2eB (B:)
dtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaedddesllg
hlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlhvlggrqmhwppg