PDB entry 5hvh

View 5hvh on RCSB PDB site
Description: Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies
Class: hydrolase/hydrolase inhibitor
Keywords: procarboxypeptidase U, thrombin-activatable fibrinolysis inhibitor, TAFI, procarboxypeptidase R, plasma procarboxypeptidase B, nanobody, antibody fragment, protein complex, HYDROLASE/HYDROLASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2016-01-28, released 2016-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4 (0-400)
      • engineered mutation (304)
      • engineered mutation (328)
      • engineered mutation (332)
      • engineered mutation (334)
  • Chain 'B':
    Compound: VHH-a204
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HVH
    Domains in SCOPe 2.08: d5hvhb1, d5hvhb2, d5hvhb3
  • Chain 'C':
    Compound: VHH-i83
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HVH
    Domains in SCOPe 2.08: d5hvhc1, d5hvhc2, d5hvhc3
  • Heterogens: NAG, ZN

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hvhB (B:)
qvqlqesggglvqpggslrlscaasgsifsgnamgwyrqapgkqrelvaaitsggstdya
dsvkgrftisrdnakntvylqmnslkpedtavyychvdprpwgydvtdydywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5hvhB (B:)
qlqesggglvqpggslrlscaasgsifsgnamgwyrqapgkqrelvaaitsggstdyads
vkgrftisrdnakntvylqmnslkpedtavyychvdprpwgydvtdydywgqgtqvtvss

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hvhC (C:)
qvqlqesggglvqaggslrlscaasgsifspnamgwyrqapgkerelvaartnvgstyad
svkgrftvsrdnakntvylqmnslkpedtavyycnawgqdgwlgqydywgqgtqvtvssh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5hvhC (C:)
vqlqesggglvqaggslrlscaasgsifspnamgwyrqapgkerelvaartnvgstyads
vkgrftvsrdnakntvylqmnslkpedtavyycnawgqdgwlgqydywgqgtqvtvss