PDB entry 5hrn

View 5hrn on RCSB PDB site
Description: HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002
Class: transferase/inhibitor
Keywords: Viral DNA integration, DNA Binding, LEDGF Binding, VIRAL PROTEIN, TRANSFERASE-INHIBITOR complex
Deposited on 2016-01-23, released 2016-12-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-12-14, with a file datestamp of 2016-12-09.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrase
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • conflict (74)
      • conflict (78)
      • engineered mutation (136)
    Domains in SCOPe 2.06: d5hrna_
  • Heterogens: CAC, SO4, EDO, 65P, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hrnA (A:)
gmhgqvdcspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrw
pvktihtdngsnftsatvkaacwwagikqefgipynpqsqgvvesmnkelkkiigqvrdq
aehlktavqmavfihnkkrkggiggysagerivdiiatdiqtke

    Sequence, based on observed residues (ATOM records): (download) 
    >5hrnA (A:)
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktihtd
ngsnftsatvkaacwwagikqefgipynpqsqgvvesmnkelkkiigqvrdqaehlktav
qmavfihnkkrkgysagerivdiiatdi