PDB entry 5hqy

View 5hqy on RCSB PDB site
Description: human dihydrofolate reductase complex with NADPH and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: OXIDOREDUCTASE ternary complex with trifluoromethyl inhibitor, OXIDOREDUCTASE, oxidoreductase-oxidoreductase inhibitor complex
Deposited on 2016-01-22, released 2017-01-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: Dhfr
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5hqya_
  • Heterogens: NDP, 63Y, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5hqyA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd