PDB entry 5hor

View 5hor on RCSB PDB site
Description: Crystal structure of c-Met-M1250T in complex with SAR125844.
Class: transferase
Keywords: TRANSFERASE, inhibitor
Deposited on 2016-01-19, released 2016-11-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-11-23, with a file datestamp of 2016-11-18.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581
      • engineered mutation (145)
      • engineered mutation (201)
    Domains in SCOPe 2.06: d5hora_
  • Heterogens: 63K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5horA (A:)
    ntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihca
    vkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnf
    irnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglard
    mydkefdsvhnktgaklpvkwtaleslqtqkfttksdvwsfgvllwelmtrgappypdvn
    tfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigeh
    yvhvnatyvnvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >5horA (A:)
    qavqhvvigpgcvyhgtlkihcavksvsqfltegiimkdfshpnvlsllgiclrsegspl
    vvlpymkhgdlrnfirnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmlde
    kftvkvadfglardmlpvkwtaleslqtqkfttksdvwsfgvllwelmtrgappypdvnt
    fditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehy
    vhvnaty