PDB entry 5hmk
View 5hmk on RCSB PDB site
Description: HDM2 in complex with a 3,3-Disubstituted Piperidine
Class: ligase/ligase inhibitor
Keywords: Oncology, E3 ubiquitin-protein ligase, p53/TP53, ligase-ligase inhibitor complex
Deposited on
2016-01-16, released
2016-04-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2016-04-06, with a file datestamp of
2016-04-01.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: N/A
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: E3 ubiquitin-protein ligase Mdm2
Species: Homo sapiens [TaxId:9606]
Gene: MDM2
Database cross-references and differences (RAF-indexed):
- Uniprot Q00987
- engineered mutation (38)
- engineered mutation (59)
Domains in SCOPe 2.08: d5hmka_ - Chain 'B':
Compound: E3 ubiquitin-protein ligase Mdm2
Species: Homo sapiens [TaxId:9606]
Gene: MDM2
Database cross-references and differences (RAF-indexed):
- Uniprot Q00987
- engineered mutation (38)
- engineered mutation (59)
Domains in SCOPe 2.08: d5hmkb_ - Heterogens: 62Q, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5hmkA (A:)
sqipaseqetlvrpkplllkllksvgaqkdtytmkevlyylgqyimtkrlydekqqhivh
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen
Sequence, based on observed residues (ATOM records): (download)
>5hmkA (A:)
tlvrpkplllkllksvgaqkdtytmkevlyylgqyimtkrlydekqqhivhcsndllgdl
fgvpsfsvkehrkiytmiyrnlvvvn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5hmkB (B:)
sqipaseqetlvrpkplllkllksvgaqkdtytmkevlyylgqyimtkrlydekqqhivh
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqessdsgtsvsen
Sequence, based on observed residues (ATOM records): (download)
>5hmkB (B:)
aseqetlvrpkplllkllksvgaqkdtytmkevlyylgqyimtkrlydekqqhivhcsnd
llgdlfgvpsfsvkehrkiytmiyrnlvvvn