PDB entry 5hkw

View 5hkw on RCSB PDB site
Description: Crystal Structure of Apo c-Cbl TKBD Refined to 2.25 A Resolution
Class: ligase
Keywords: SPRY2, Cbl, Protein-protein interaction, anticancer target, LIGASE
Deposited on 2016-01-14, released 2017-01-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: Homo sapiens [TaxId:9606]
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hkwa1, d5hkwa2, d5hkwa3
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: Homo sapiens [TaxId:9606]
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hkwb1, d5hkwb2, d5hkwb3
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: Homo sapiens [TaxId:9606]
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hkwc1, d5hkwc2, d5hkwc3
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hkwA (A:)
snappgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsrye
gkmetlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmla
elkgifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleama
lkstidltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqk
fihkpgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgr
nqnpdltg

    Sequence, based on observed residues (ATOM records): (download) 
    >5hkwA (A:)
pgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkme
tlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkg
ifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkst
idltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihk
pgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnp
dl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hkwB (B:)
snappgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsrye
gkmetlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmla
elkgifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleama
lkstidltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqk
fihkpgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgr
nqnpdltg

    Sequence, based on observed residues (ATOM records): (download) 
    >5hkwB (B:)
pgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkme
tlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkg
ifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkst
idltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihk
pgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnp
dl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hkwC (C:)
snappgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsrye
gkmetlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmla
elkgifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleama
lkstidltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqk
fihkpgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgr
nqnpdltg

    Sequence, based on observed residues (ATOM records): (download) 
    >5hkwC (C:)
pgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkme
tlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkg
ifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkst
idltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihk
pgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnp
dl