PDB entry 5hk5

View 5hk5 on RCSB PDB site
Description: Structure of the Grem2-GDF5 Inhibitory Complex
Class: cytokine
Keywords: DAN-family, Bone Morphogenetic Proteins, CYTOKINE
Deposited on 2016-01-13, released 2016-08-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GDF5, BMP14, CDMP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hk5a_
  • Chain 'B':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GDF5, BMP14, CDMP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hk5b_
  • Chain 'C':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GDF5, BMP14, CDMP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hk5c_
  • Chain 'D':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GDF5, BMP14, CDMP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hk5d_
  • Chain 'E':
    Compound: Gremlin-2
    Species: Mus musculus [TaxId:10090]
    Gene: Grem2, Cktsf1b2, Prdc
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Gremlin-2
    Species: Mus musculus [TaxId:10090]
    Gene: Grem2, Cktsf1b2, Prdc
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Gremlin-2
    Species: Mus musculus [TaxId:10090]
    Gene: Grem2, Cktsf1b2, Prdc
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Gremlin-2
    Species: Mus musculus [TaxId:10090]
    Gene: Grem2, Cktsf1b2, Prdc
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hk5A (A:)
aplatrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshl
eptnhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >5hk5A (A:)
karcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshleptnhaviqtlmnsm
dpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hk5B (B:)
aplatrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshl
eptnhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >5hk5B (B:)
karcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshleptnhaviqtlmnsm
dpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hk5C (C:)
aplatrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshl
eptnhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >5hk5C (C:)
karcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshleptnhaviqtlmnsm
dpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5hk5D (D:)
aplatrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshl
eptnhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >5hk5D (D:)
karcsrkalhvnfkdmgwddwiiapleyeafhceglcefplrshleptnhaviqtlmnsm
dpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.