PDB entry 5hjp

View 5hjp on RCSB PDB site
Description: Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
Class: signaling protein
Keywords: Agonist, Alzheimer's, SIGNALING PROTEIN
Deposited on 2016-01-13, released 2016-04-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-04-27, with a file datestamp of 2016-04-22.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoic acid receptor RXR-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: RXRB, NR2B2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28702 (0-End)
      • expression tag (242-249)
    Domains in SCOPe 2.08: d5hjpa1, d5hjpa2
  • Chain 'B':
    Compound: oxysterols receptor lxr-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1H2, LXRB, NER, UNR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55055 (0-244)
      • engineered mutation (42)
      • engineered mutation (44-45)
      • engineered mutation (47)
      • expression tag (245-260)
    Domains in SCOPe 2.08: d5hjpb1, d5hjpb2
  • Chain 'C':
    Compound: Retinoic acid receptor RXR-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: RXRB, NR2B2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28702 (0-End)
      • expression tag (242-249)
    Domains in SCOPe 2.08: d5hjpc1, d5hjpc2
  • Chain 'D':
    Compound: oxysterols receptor lxr-beta
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1H2, LXRB, NER, UNR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55055 (Start-244)
      • engineered mutation (45)
      • engineered mutation (47)
      • expression tag (245-260)
    Domains in SCOPe 2.08: d5hjpd1, d5hjpd2
  • Heterogens: 668, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hjpA (A:)
mpvdrileaelaveqksdqgvegpggtggsgsspndpvtnicqaadkqlftlvewakrip
hfsslplddqvillragwnelliasfshrsidvrdgillatglhvhrnsahsagvgaifd
rvltelvskmrdmrmdktelgclraiilfnpdakglsnpsevevlrekvyasletyckqk
ypeqqgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphqlagsgsg
shkilhrllqdsss

    Sequence, based on observed residues (ATOM records): (download) 
    >5hjpA (A:)
mpvdrileaelavevtnicqaadkqlftlvewakriphfsslplddqvillragwnelli
asfshrsidvrdgillatglhvhrnsahsagvgaifdrvltelvskmrdmrmdktelgcl
raiilfnpdakglsnpsevevlrekvyasletyckqkypeqqgrfaklllrlpalrsigl
kclehlfffkligdtpidtflmemleakilhrllq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hjpB (B:)
gvqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwplgadpasgsasqqrfahftelai
isvqeivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflkdftys
kddfhraglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgrvealq
qpyveallsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklppllsei
wdvhegsgsgshkilhrllqdsss

    Sequence, based on observed residues (ATOM records): (download) 
    >5hjpB (B:)
gvqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwpadpasgsasqqrfahftelaiis
vqeivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflkdftyskd
dfhraglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgrvealqqp
yveallsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklppllseiwd
vhegsgsgshkilhrllqd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hjpC (C:)
mpvdrileaelaveqksdqgvegpggtggsgsspndpvtnicqaadkqlftlvewakrip
hfsslplddqvillragwnelliasfshrsidvrdgillatglhvhrnsahsagvgaifd
rvltelvskmrdmrmdktelgclraiilfnpdakglsnpsevevlrekvyasletyckqk
ypeqqgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphqlagsgsg
shkilhrllqdsss

    Sequence, based on observed residues (ATOM records): (download) 
    >5hjpC (C:)
mpvdrileaelavepvtnicqaadkqlftlvewakriphfsslplddqvillragwnell
iasfshrsidvrdgillatglhvhrnsahsagvgaifdrvltelvskmrdmrmdktelgc
lraiilfnpdakglsnpsevevlrekvyasletyckqkypeqqgrfaklllrlpalrsig
lkclehlfffkligdtpidtflmemleakilhrllq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5hjpD (D:)
gvqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwplgadpasgsasqqrfahftelai
isvqeivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflkdftys
kddfhraglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgrvealq
qpyveallsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklppllsei
wdvhegsgsgshkilhrllqdsss

    Sequence, based on observed residues (ATOM records): (download) 
    >5hjpD (D:)
qltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwpsasqqrfahftelaiisvqeivdfa
kqvpgflqlgredqiallkastieimlletarrynhetecitflkdftyskddfhraglq
vefinpifefsramrrlglddaeyalliainifsadrpnvqepgrvealqqpyveallsy
trikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklppllseiwdvhegsgsg
shkilhrllqd