PDB entry 5hgg

View 5hgg on RCSB PDB site
Description: Crystal structure of uPA in complex with a camelid-derived antibody fragment
Class: hydrolase/inhibitor
Keywords: uPA, Nanobody, Serine Protease, HYDROLASE-INHIBITOR complex
Deposited on 2016-01-08, released 2016-06-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-08-10, with a file datestamp of 2016-08-05.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: urokinase-type plasminogen activator
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00749 (0-245)
      • engineered mutation (120)
      • engineered mutation (143)
    Domains in SCOPe 2.07: d5hgga_
  • Chain 'B':
    Compound: urokinase-type plasminogen activator
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00749 (0-245)
      • engineered mutation (120)
      • engineered mutation (143)
    Domains in SCOPe 2.07: d5hggb_
  • Chain 'S':
    Compound: Camelid Derived Antibody Fragment, Nb4
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HGG (0-127)
    Domains in SCOPe 2.07: d5hggs_
  • Chain 'T':
    Compound: Camelid Derived Antibody Fragment, Nb4
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HGG (0-End)
    Domains in SCOPe 2.07: d5hggt1, d5hggt2
  • Heterogens: GOL, SO4, TWN, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5hggA (A:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslispcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
alpsmyndpqfgtsceitgfgkeqstdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtk

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5hggB (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslispcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
alpsmyndpqfgtsceitgfgkeqstdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtk

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5hggS (S:)
qvqlqesggglvqaggslrlscaasgftldsyaigwfrqapgkeregvscisasggstny
adsvkgrftisrdnakntvylqmnslksedtavyycaadhpglctsesgrrrylevwgqg
tqvtvssa

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >5hggT (T:)
qvqlqesggglvqaggslrlscaasgftldsyaigwfrqapgkeregvscisasggstny
adsvkgrftisrdnakntvylqmnslksedtavyycaadhpglctsesgrrrylevwgqg
tqvtvssa

    Sequence, based on observed residues (ATOM records): (download) 
    >5hggT (T:)
qvqlqesggglvqaggslrlscaasgftldsyaigwfrqapgkeregvscisasggstny
adsvkgrftisrdnakntvylqmnslksedtavyycaadhpglctsesgrrrylevwgqg
tqvtvss