PDB entry 5hem

View 5hem on RCSB PDB site
Description: Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
Class: transcription
Keywords: Transcription regulation, post translational modifications recognition, transcription
Deposited on 2016-01-06, released 2016-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-01-20, with a file datestamp of 2016-01-15.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440 (2-End)
      • expression tag (1)
      • engineered mutation (92)
    Domains in SCOPe 2.08: d5hema1, d5hema2
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440
      • engineered mutation (92)
    Domains in SCOPe 2.08: d5hemb_
  • Heterogens: EDO, ACT, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hemA (A:)
smkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikr
rlennyywaasecmqdfntmftncyiynkptdyivlmaqtlekiflqkvasmpqeeqelv
vtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >5hemA (A:)
mkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrr
lennyywaasecmqdfntmftncyiynkptdyivlmaqtlekiflqkvasmpqeeqelvv
t

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hemB (B:)
smkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikr
rlennyywaasecmqdfntmftncyiynkptdyivlmaqtlekiflqkvasmpqeeqelv
vtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >5hemB (B:)
pgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrle
nnyywaasecmqdfntmftncyiynkptdyivlmaqtlekiflqkvasmpqeeqel