PDB entry 5he1

View 5he1 on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG224062
Class: transferase/transferase inhibitor
Keywords: RGS, kinase, PH, WD-40, inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-01-05, released 2016-05-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-05-11, with a file datestamp of 2016-05-06.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5he1a1, d5he1a2, d5he1a3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5he1b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P59768
      • engineered mutation (67)
    Domains in SCOPe 2.06: d5he1g_
  • Heterogens: ZS2, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5he1A (A:)
skkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyee
ikkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqp
yieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygc
rkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkls
fildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldeh
ghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrgh
spfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevk
espffrsldwqmvflqkyppplipprgevnaadafdigsfdeedtkgiklldsdqelyrn
fpltiserwqqevaetvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskm
gnpfltqwqrryfylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggk
qfilqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkpra

    Sequence, based on observed residues (ATOM records): (download) 
    >5he1A (A:)
skkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyee
ikkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqp
yieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygc
rkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkls
fildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldeh
ghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrgh
spfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevk
espffrsldwqmvflqkyppplipptkgiklldsdqelyrnfpltiserwqqevaetvfd
tinaetdrlearkkaknkheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlew
rgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrda
yreaqqlvqrvpkmknkp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5he1B (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5he1G (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >5he1G (G:)
asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkf
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