PDB entry 5he1

View 5he1 on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG224062
Class: transferase/transferase inhibitor
Keywords: RGS, kinase, PH, WD-40, inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-01-05, released 2016-05-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ADRBK1, BARK, BARK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5he1a1, d5he1a2, d5he1a3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5he1b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P59768
      • engineered mutation (67)
    Domains in SCOPe 2.07: d5he1g_
  • Heterogens: ZS2, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5he1A (A:)
    skkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyee
    ikkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqp
    yieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygc
    rkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkls
    fildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldeh
    ghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrgh
    spfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevk
    espffrsldwqmvflqkyppplipprgevnaadafdigsfdeedtkgiklldsdqelyrn
    fpltiserwqqevaetvfdtinaetdrlearkkaknkqlgheedyalgkdcimhgymskm
    gnpfltqwqrryfylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggk
    qfilqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkpra
    

    Sequence, based on observed residues (ATOM records): (download)
    >5he1A (A:)
    skkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyee
    ikkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqp
    yieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygc
    rkadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdkls
    fildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldeh
    ghvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrgh
    spfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevk
    espffrsldwqmvflqkyppplipptkgiklldsdqelyrnfpltiserwqqevaetvfd
    tinaetdrlearkkaknkheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlew
    rgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrda
    yreaqqlvqrvpkmknkp
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5he1B (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5he1G (G:)
    masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
    frekkffsail
    

    Sequence, based on observed residues (ATOM records): (download)
    >5he1G (G:)
    asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrekkf
    fs