PDB entry 5hcz
View 5hcz on RCSB PDB site
Description: EGFR kinase domain mutant "TMLR" with 3-azetidinyl azaindazole compound 21
Class: transferase/transferase inhibitor
Keywords: protein kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2016-01-04, released
2016-09-07
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-09-07, with a file datestamp of
2016-09-02.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.19
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (2-End)
- engineered mutation (96)
- engineered mutation (164)
Domains in SCOPe 2.06: d5hcza_ - Heterogens: SO4, 60E, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5hczA (A:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqgns
Sequence, based on observed residues (ATOM records): (download)
>5hczA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikeltspkanke
ildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwc
vqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriyt
hqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwm
idadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfydmddvvdadeylip