PDB entry 5hcz

View 5hcz on RCSB PDB site
Description: EGFR kinase domain mutant "TMLR" with 3-azetidinyl azaindazole compound 21
Class: transferase/transferase inhibitor
Keywords: protein kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-01-04, released 2016-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-10-26, with a file datestamp of 2016-10-21.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (2-End)
      • engineered mutation (96)
      • engineered mutation (164)
    Domains in SCOPe 2.08: d5hcza_
  • Heterogens: SO4, 60E, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hczA (A:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqgns

    Sequence, based on observed residues (ATOM records): (download) 
    >5hczA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikeltspkanke
ildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwc
vqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriyt
hqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwm
idadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfydmddvvdadeylip