PDB entry 5hcv

View 5hcv on RCSB PDB site
Description: Identification of Spirooxindole and Dibenzoxazepine Motifs as Potent Mineralocorticoid Receptor Antagonists
Class: signaling protein
Keywords: Mineralocorticoid Receptor, Ligand-binding domain, MR-LBD, Antagonists, co-crystal, SIGNALING PROTEIN
Deposited on 2016-01-04, released 2016-03-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-09, with a file datestamp of 2017-08-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered mutation (80)
    Domains in SCOPe 2.08: d5hcva_
  • Chain 'B':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered mutation (80)
    Domains in SCOPe 2.08: d5hcvb_
  • Chain 'C':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered mutation (80)
    Domains in SCOPe 2.08: d5hcvc_
  • Heterogens: 60R, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hcvA (A:)
gshmraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvl
pgfknlpledqitliqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamye
lcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmv
tkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdq
lpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hcvA (A:)
pvmvleniepeivyagypdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitl
iqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvr
lqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvnsgqswqrfyqltk
lldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hcvB (B:)
gshmraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvl
pgfknlpledqitliqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamye
lcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmv
tkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdq
lpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hcvB (B:)
pvmvleniepeivyagypdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitl
iqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvr
lqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvswqrfyqltkllds
mhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hcvC (C:)
gshmraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvl
pgfknlpledqitliqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamye
lcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmv
tkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdq
lpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hcvC (C:)
pvmvleniepeivyagypdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitl
iqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvr
lqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvswqrfyqltkllds
mhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvnakplyfh