PDB entry 5h8s

View 5h8s on RCSB PDB site
Description: Structure of the human GluA2 LBD in complex with GNE3419
Class: transport protein
Keywords: GluN1, GluN2A, NMDA, receptor, TRANSPORT PROTEIN
Deposited on 2015-12-23, released 2016-02-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor 2,Glutamate receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42262 (2-116)
      • linker (117-118)
    • Uniprot P42262 (119-End)
      • engineered mutation (230)
      • variant (241)
    Domains in SCOPe 2.08: d5h8sa_
  • Chain 'B':
    Compound: Glutamate receptor 2,Glutamate receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42262 (2-116)
      • linker (117-118)
    • Uniprot P42262 (119-End)
      • engineered mutation (230)
      • variant (241)
    Domains in SCOPe 2.08: d5h8sb_
  • Chain 'C':
    Compound: Glutamate receptor 2,Glutamate receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42262 (2-116)
      • expression tag (0-1)
      • linker (117-118)
    • Uniprot P42262 (119-End)
      • engineered mutation (230)
      • variant (241)
    Domains in SCOPe 2.08: d5h8sc1, d5h8sc2
  • Heterogens: GLU, 5YC, ZN, CAC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5h8sA (A:)
gsnktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5h8sA (A:)
nktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkyg
ardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtpie
saedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvr
kskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlkls
eqglldklknkwwydkgec

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5h8sB (B:)
gsnktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5h8sB (B:)
nktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkyg
ardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtpie
saedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvr
kskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlkls
eqglldklknkwwydkgec

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5h8sC (C:)
gsnktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5h8sC (C:)
gsnktvvvttilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgk
ygardadtkiwngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkgtp
iesaedlskqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvar
vrkskgkyayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlk
lseqglldklknkwwydkgecg