PDB entry 5g4n
View 5g4n on RCSB PDB site
Description: Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083
Class: transcription
Keywords: transcription, p53, cancer, tumor suppression, DNA binding, cancer therapy, small-molecule stabilizers, molecular chaperone, fluorine-protein interactions
Deposited on
2016-05-13, released
2016-06-22
The last revision prior to the SCOPe 2.07 freeze date was dated
2016-09-28, with a file datestamp of
2016-09-23.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: N/A
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.07: d5g4na_ - Chain 'B':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04637 (0-End)
- engineered mutation (39)
- engineered mutation (109)
- engineered mutation (126)
- engineered mutation (145)
- engineered mutation (174)
Domains in SCOPe 2.07: d5g4nb_ - Heterogens: ZN, O83, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5g4nA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>5g4nA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhs
vvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvc
acpgrdrrteeenlrkk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5g4nB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt
Sequence, based on observed residues (ATOM records): (download)
>5g4nB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpceppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdrrteeenlr