PDB entry 5g3n

View 5g3n on RCSB PDB site
Description: Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.
Class: hydrolase
Keywords: hydrolase, spla2, secreted phospholipase a2, cardiovascular disease, inhibitor, fragment
Deposited on 2016-04-29, released 2016-09-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phospholipase A2, membrane associated
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14555 (0-123)
      • engineered mutation (0)
      • engineered mutation (75)
      • expression tag (124-126)
    Domains in SCOPe 2.08: d5g3na1, d5g3na2
  • Chain 'B':
    Compound: Phospholipase A2, membrane associated
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14555 (0-123)
      • engineered mutation (0)
      • engineered mutation (75)
      • expression tag (124)
    Domains in SCOPe 2.08: d5g3nb1, d5g3nb2
  • Heterogens: CA, FMT, X28, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5g3nA (A:)
alvnfhrmiklttgkeaalsygfygchcgvggrgspkdatdrccvthdccykrlekrgcg
tkflsykfsnsgsriscakqdscrsqlcecdkaaatcfarnkttynkkyqyysnkhcrgs
tprcghh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5g3nB (B:)
alvnfhrmiklttgkeaalsygfygchcgvggrgspkdatdrccvthdccykrlekrgcg
tkflsykfsnsgsriscakqdscrsqlcecdkaaatcfarnkttynkkyqyysnkhcrgs
tprcghh

    Sequence, based on observed residues (ATOM records): (download) 
    >5g3nB (B:)
alvnfhrmiklttgkeaalsygfygchcgvggrgspkdatdrccvthdccykrlekrgcg
tkflsykfsnsgsriscakqdscrsqlcecdkaaatcfarnkttynkkyqyysnkhcrgs
tprcg