PDB entry 5g03

View 5g03 on RCSB PDB site
Description: An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
Class: lyase
Keywords: lyase, natural product inhibitor, protein engineering, carbonic anhydrase
Deposited on 2016-03-16, released 2016-05-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00918 (Start-259)
      • engineered mutation (64)
      • engineered mutation (66)
      • engineered mutation (68)
      • engineered mutation (90)
      • engineered mutation (129-130)
      • engineered mutation (133)
      • engineered mutation (168)
      • engineered mutation (202)
      • engineered mutation (204)
    Domains in SCOPe 2.08: d5g03a_
  • Heterogens: ZN, SO4, OE2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5g03A (A:)
mshhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslril
nnghsfqvtfddsqdkavlkggpldgtyrllqfhfhwgsldgqgsehtvdkkkyaaelhl
vhwntkygdvdkalqqpdglavlgiflkvgsakpglqkvvdvldsiktegksadftnfdp
rgllpesldywtypgslttpplaegvtwivlkepisvsseqvlkfrklnfngegepeelm
vdnwrpaqplknrqikasfk

    Sequence, based on observed residues (ATOM records): (download) 
    >5g03A (A:)
hwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnng
hsfqvtfddsqdkavlkggpldgtyrllqfhfhwgsldgqgsehtvdkkkyaaelhlvhw
ntkygdvdkalqqpdglavlgiflkvgsakpglqkvvdvldsiktegksadftnfdprgl
lpesldywtypgslttpplaegvtwivlkepisvsseqvlkfrklnfngegepeelmvdn
wrpaqplknrqikasfk