PDB entry 5fz7

View 5fz7 on RCSB PDB site
Description: Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment ethyl 2-amino-4-thiophen-2-ylthiophene-3- carboxylate (N06131b) (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)
Class: oxidoreductase
Keywords: oxidoreductase, jarid1b, plu1, fragment screening, structural genomics consortium, sgc, diamond i04-1, pandda
Deposited on 2016-03-11, released 2016-03-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific demethylase 5B
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGL1 (82-End)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d5fz7a1, d5fz7a2, d5fz7a3
  • Heterogens: ZN, DMS, MN, PO4, EDO, CL, WGT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5fz7A (A:)
smflpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhf
tpriqrlneleaqtrvklggggardytlrtfgemadafksdyfnmpvhmvptelvekefw
rlvstieedvtveygadiaskefgsgfpvrdgkiklspeeeeyldsgwnlnnmpvmeqsv
lahitadicgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqle
nvmkklapelfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfn
qgfnfaeavnfctvdwlplgrqcvehyrllhrycvfshdemickmaskadvldvvvastv
qkdmaimiedekalretvrklgvidsermdfellpdderqcvkckttcfmsaiscsckpg
llvclhhvkelcscppykyklryrytlddlypmmnalklraesynewalnvnealeaki

    Sequence, based on observed residues (ATOM records): (download) 
    >5fz7A (A:)
smflpppecpvfepsweefadpfafihkirpiaeqtgickvrpppdwqppfacdvdklhf
tpriqrlneleaqtrvkardytlrtfgemadafksdyfnmpvhmvptelvekefwrlvst
ieedvtveygadiaskefgsgfpvrdiklspeeeeyldsgwnlnnmpvmeqsvlahitad
icgmklpwlyvgmcfssfcwhiedhwsysinylhwgepktwygvpgyaaeqlenvmkkla
pelfvsqpdllhqlvtimnpntlmthevpvyrtnqcagefvitfprayhsgfnqgfnfae
avnfctvdwlplgrqcvehyrllhrycvfshdemickmaskadvldvvvastvqkdmaim
iedekalretvrklgvidsermdfellpdderqcvkckttcfmsaiscsckpgllvclhh
vkelcscppykyklryrytlddlypmmnalklrae