PDB entry 5fhz

View 5fhz on RCSB PDB site
Description: Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid
Class: oxidoreductase
Keywords: Human, retinaldehyde dehydrogenase, tetramer, product-bound structure, oxidoreductase
Deposited on 2015-12-22, released 2016-11-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-11-02, with a file datestamp of 2016-10-28.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhza_
  • Chain 'B':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhzb_
  • Chain 'C':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhzc_
  • Chain 'D':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhzd_
  • Chain 'E':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhze_
  • Chain 'F':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhzf_
  • Chain 'G':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhzg_
  • Chain 'H':
    Compound: Aldehyde dehydrogenase family 1 member A3
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDH1A3, ALDH6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5fhzh_
  • Heterogens: NAD, REA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5fhzA (A:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzA (A:)
alprpirnlevkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaa
qvafqrgspwrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegci
rtlryfagwadkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccg
ntmvlkpaeqtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgs
tevgklvkeaasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaas
rvfveeqvysefvrrsveyakkrpvgdpfdvkteqgpqidqkqfdkileliesgkkegak
lecggsamedkglfikptvfsevtdnmriakeeifgpvqpilkfksieevikranstdyg
ltaavftknldkalklasalesgtvwincynalyaqapfggfkmsgngrelgeyalaeyt
evktvtikl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5fhzB (B:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzB (B:)
rpirnlevkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaqva
fqrgspwrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcirtl
ryfagwadkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgntm
vlkpaeqtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgstev
gklvkeaasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasrvf
veeqvysefvrrsveyakkrpvfdvkteqgpqieliesgkkegaklecggsamedkglfi
kptvfsevtdnmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalk
lasalesgtvwincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5fhzC (C:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzC (C:)
lprpirnlevkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaq
vafqrgspwrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcir
tlryfagwadkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgn
tmvlkpaeqtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgst
evgklvkeaasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasr
vfveeqvysefvrrsveyakkrpvgdpfdvkteqgpqidqkqfdkileliesgkkegakl
ecggsamedkglfikptvfsevtdnmriakeeifgpvqpilkfksieevikranstdygl
taavftknldkalklasalesgtvwincynalyaqapfggfkmsgngrelgeyalaeyte
vktvtiklg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5fhzD (D:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzD (D:)
lprpirnlevkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaq
vafqrgspwrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcir
tlryfagwadkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgn
tmvlkpaeqtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgst
evgklvkeaasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasr
vfveeqvysefvrrsveyakkrpvgdpfdvkteqgpqidqkqfdkileliesgkkegakl
ecggsamedkglfikptvfsevtdnmriakeeifgpvqpilkfksieevikranstdygl
taavftknldkalklasalesgtvwincynalyaqapfggfkmsgngrelgeyalaeyte
vktvtikl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5fhzE (E:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzE (E:)
pirnlevkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaqvaf
qrgspwrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcirtlr
yfagwadkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgntmv
lkpaeqtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgstevg
klvkeaasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasrvfv
eeqvysefvrrsveyakkrpvgdpfdvkteqgpqidqkqfdkileliegaklecggsadk
glfikptvfsevtdnmriakeeifgpvqpilkfksieevikranstdygltaavftknld
kalklasalesgtvwincynalyaqapfggfkmsgngrelgeyalaeytevktvtikl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5fhzF (F:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzF (F:)
evkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgsp
wrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcirtlryfagw
adkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpae
qtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvke
aasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvy
sefvrrsveygdpfgpqidqkqfdkilliesgkkegaklecggsaptvfsevtdnmpvqp
ilkfksieevikranstdygltaavftknldkalklasalesgtvwincynalyaqapfg
gfkmsgngrelgeyalaeytevktvtikl

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5fhzG (G:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzG (G:)
vkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspw
rrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcirtlryfagwa
dkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeq
tpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkea
asrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvys
efvrrsveyakkrpvgdpfdvkteqgpqidqkqfdkileliesgkkegaklecgfikptv
fsevtdifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtvwi
ncynalyaqapfggfkmsgngrelgeyalaeytevktvtikl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5fhzH (H:)
hhhhhhlestslykkagmatangavengqpdrkppalprpirnlevkftkifinnewhes
ksgkkfatcnpstreqiceveegdkpdvdkaveaaqvafqrgspwrrldalsrgrllhql
adlverdratlaaletmdtgkpflhaffidlegcirtlryfagwadkiqgktiptddnvv
cftrhepigvcgaitpwnfpllmlvwklapalccgntmvlkpaeqtpltalylgslikea
gfppgvvnivpgfgptvgaaisshpqinkiaftgstevgklvkeaasrsnlkrvtlelgg
knpcivcadadldlavecahqgvffnqgqcctaasrvfveeqvysefvrrsveyakkrpv
gdpfdvkteqgpqidqkqfdkileliesgkkegaklecggsamedkglfikptvfsevtd
nmriakeeifgpvqpilkfksieevikranstdygltaavftknldkalklasalesgtv
wincynalyaqapfggfkmsgngrelgeyalaeytevktvtiklgdknp

    Sequence, based on observed residues (ATOM records): (download) 
    >5fhzH (H:)
prpirnlevkftkifinnewhesksgkkfatcnpstreqiceveegdkpdvdkaveaaqv
afqrgspwrrldalsrgrllhqladlverdratlaaletmdtgkpflhaffidlegcirt
lryfagwadkiqgktiptddnvvcftrhepigvcgaitpwnfpllmlvwklapalccgnt
mvlkpaeqtpltalylgslikeagfppgvvnivpgfgptvgaaisshpqinkiaftgste
vgklvkeaasrsnlkrvtlelggknpcivcadadldlavecahqgvffnqgqcctaasrv
fveeqvysefvrrsveyakkrpvgdpfdvkteqgpqidqkqfdkileliesgkkegakle
cggsamedkglfikptvfsevtdnmriakeeifgpvqpilkfksieevikranstdyglt
aavftknldkalklasalesgtvwincynalyaqapfggfkmsgngrelgeyalaeytev
ktvtiklg