PDB entry 5fdo

View 5fdo on RCSB PDB site
Description: Mcl-1 complexed with small molecule inhibitor
Class: apoptosis/apoptosis inhibitor
Keywords: Mcl-1, inhibitor, apoptosis-apoptosis inhibitor complex
Deposited on 2015-12-16, released 2016-03-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (1-149)
      • expression tag (0)
    Domains in SCOPe 2.08: d5fdoa1, d5fdoa2
  • Chain 'B':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (1-149)
      • expression tag (0)
    Domains in SCOPe 2.08: d5fdob1, d5fdob2
  • Chain 'C':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (1-149)
      • expression tag (0)
    Domains in SCOPe 2.08: d5fdoc1, d5fdoc2
  • Chain 'D':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (1-149)
      • expression tag (0)
    Domains in SCOPe 2.08: d5fdod1, d5fdod2
  • Heterogens: 5X2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5fdoA (A:)
gdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqg
mlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepl
aesitdvlvrtkrdwlvkqrgwdgfveffh

    Sequence, based on observed residues (ATOM records): (download) 
    >5fdoA (A:)
gdelyrqsleiisrylreqatgakgatsrkaletlrrvgdgvqrnhetafqgmlrkldik
neddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvl
vrtkrdwlvkqrgwdgfveffh

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5fdoB (B:)
gdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqg
mlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepl
aesitdvlvrtkrdwlvkqrgwdgfveffh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5fdoC (C:)
gdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqg
mlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepl
aesitdvlvrtkrdwlvkqrgwdgfveffh

    Sequence, based on observed residues (ATOM records): (download) 
    >5fdoC (C:)
gdelyrqsleiisrylreqatgakdgatsrkaletlrrvgdgvqrnhetafqgmlrkldi
kneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdv
lvrtkrdwlvkqrgwdgfveffh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5fdoD (D:)
gdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqg
mlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepl
aesitdvlvrtkrdwlvkqrgwdgfveffh

    Sequence, based on observed residues (ATOM records): (download) 
    >5fdoD (D:)
gdelyrqsleiisrylreqatgatsrkaletlrrvgdgvqrnhetafqgmlrkldikned
dvkslsrvmihvfsvtnwgrivtlisfgafvakhlktinqescieplaesitdvlvrtkr
dwlvkqrgwdgfveffh