PDB entry 5ew0

View 5ew0 on RCSB PDB site
Description: Crystal structure of the metallo-beta-lactamase Sfh-I in complex with the bisthiazolidine inhibitor L-CS319
Class: hydrolase
Keywords: inhibitor, carbapenemase, antibiotic resistance, hydrolase
Deposited on 2015-11-20, released 2016-06-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-06-01, with a file datestamp of 2016-05-27.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: N/A
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Serratia fonticola [TaxId:47917]
    Gene: sfhI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ew0a_
  • Chain 'B':
    Compound: Beta-lactamase
    Species: Serratia fonticola [TaxId:47917]
    Gene: sfhI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ew0b_
  • Heterogens: ZN, 3C7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ew0A (A:)
gpseknltlthfkgplyivedkeyvqensmvyigtdgitiigatwtpetaetlykeirkv
splpinevintnyhtdraggnaywktlgakivatqmtydlqksqwgsivnftrqgnnkyp
nlekslpdtvfpgdfnlqngsiramylgeahtkdgifvyfpaervlygncilkenlgnms
fanrteypktleklkglieqgelkvdsiiaghdtpihdvglidhyltllekapk

    Sequence, based on observed residues (ATOM records): (download) 
    >5ew0A (A:)
nltlthfkgplyivedkeyvqensmvyigtdgitiigatwtpetaetlykeirkvsplpi
nevintnyhtdraggnaywktlgakivatqmtydlqksqwgsivnftrqgnnkypnleks
lpdtvfpgdfnlqngsiramylgeahtkdgifvyfpaervlygncilkenlgnmsfanrt
eypktleklkglieqgelkvdsiiaghdtpihdvglidhyltllekap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ew0B (B:)
gpseknltlthfkgplyivedkeyvqensmvyigtdgitiigatwtpetaetlykeirkv
splpinevintnyhtdraggnaywktlgakivatqmtydlqksqwgsivnftrqgnnkyp
nlekslpdtvfpgdfnlqngsiramylgeahtkdgifvyfpaervlygncilkenlgnms
fanrteypktleklkglieqgelkvdsiiaghdtpihdvglidhyltllekapk

    Sequence, based on observed residues (ATOM records): (download) 
    >5ew0B (B:)
nltlthfkgplyivedkeyvqensmvyigtdgitiigatwtpetaetlykeirkvsplpi
nevintnyhtdraggnaywktlgakivatqmtydlqksqwgsivnftrqgnnkypnleks
lpdtvfpgdfnlqngsiramylgeahtkdgifvyfpaervlygncilkenlgnmsfanrt
eypktleklkglieqgelkvdsiiaghdtpihdvglidhyltllekap