PDB entry 5etj

View 5etj on RCSB PDB site
Description: Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate
Class: Transferase/Transferase Inhibitor
Keywords: phosphorylase, Transferase-Transferase Inhibitor complex
Deposited on 2015-11-17, released 2016-09-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (33-34)
      • conflict (85)
      • engineered mutation (292)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d5etja1, d5etja2
  • Chain 'B':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (34)
      • conflict (85)
      • engineered mutation (292)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d5etjb1, d5etjb2
  • Chain 'C':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (33-34)
      • conflict (85)
      • engineered mutation (292)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d5etjc1, d5etjc2
  • Chain 'D':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (33-34)
      • conflict (85)
      • engineered mutation (292)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d5etjd1, d5etjd2
  • Chain 'E':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (33-34)
      • conflict (85)
      • engineered mutation (292)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d5etje1, d5etje2
  • Chain 'F':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: PNP, NP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491 (35-End)
      • expression tag (33-34)
      • conflict (85)
      • engineered mutation (292)
      • engineered mutation (295)
    Domains in SCOPe 2.08: d5etjf1, d5etjf2
  • Heterogens: IM5, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5etjA (A:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
    qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
    hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
    plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
    crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanhdevaaagk
    qaaqkleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5etjA (A:)
    tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
    stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
    glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstw
    kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
    slitnkvimdyeslekanhdevaaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5etjB (B:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
    qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
    hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
    plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
    crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanhdevaaagk
    qaaqkleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5etjB (B:)
    lmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprs
    tvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagg
    lnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwk
    qmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfs
    litnkvimdyeslekanhdevaaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5etjC (C:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
    qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
    hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
    plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
    crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanhdevaaagk
    qaaqkleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5etjC (C:)
    tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
    stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
    glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstw
    kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
    slitnkvimdyeslekanhdevaaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5etjD (D:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
    qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
    hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
    plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
    crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanhdevaaagk
    qaaqkleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5etjD (D:)
    tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
    stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
    glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstw
    kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
    slitnkvimdyeslekanhdevaaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5etjE (E:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
    qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
    hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
    plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
    crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanhdevaaagk
    qaaqkleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5etjE (E:)
    tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
    stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
    glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstw
    kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
    slitnkvimdyeslekanhdevaaagkqaaqkleqfvsilmasiplpd
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5etjF (F:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaewllshtkhrp
    qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
    hmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
    plrgpnderfgdrfpamsdaydrtmrqralstwkqmgeqrelqegtyvmvagpsfetvae
    crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanhdevaaagk
    qaaqkleqfvsilmasiplpdkas
    

    Sequence, based on observed residues (ATOM records): (download)
    >5etjF (F:)
    tlmengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
    stvpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaag
    glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstw
    kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
    slitnkvimdyeslekanhdevaaagkqaaqkleqfvsilmasiplpd