PDB entry 5esb
View 5esb on RCSB PDB site
Description: Crystal structure of a genotype 1a/3a chimeric HCV NS3/4A protease in complex with Vaniprevir
Class: hYDROLASE/hYDROLASE iNHIBITOR
Keywords: Vaniprevir, drug resistance, HCV protease inhibitor, Genotype 3, HYDROLASE, hYDROLASE-hYDROLASE iNHIBITOR complex
Deposited on
2015-11-16, released
2016-11-30
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-12-11, with a file datestamp of
2019-12-06.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: NS3 protease
Species: Hepatitis C virus [TaxId:11103]
Database cross-references and differences (RAF-indexed):
- Uniprot C1KIK8 (17-192)
- expression tag (0-16)
- conflict (26-27)
- conflict (30-31)
- conflict (34)
- conflict (53)
- conflict (60)
- conflict (65)
- conflict (85)
- conflict (99)
- engineered mutation (136)
- engineered mutation (145)
- conflict (172)
- engineered mutation (181)
Domains in SCOPe 2.08: d5esba1, d5esba2 - Heterogens: ZN, SO4, SU3, HOH