PDB entry 5eol

View 5eol on RCSB PDB site
Description: Crystal structure of human Pim-1 kinase in complex with a macrocyclic quinoxaline-pyrrolodihydropiperidinone inhibitor
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE, serine/threonine protein kinase, transferase-transferase inhibitor complex
Deposited on 2015-11-10, released 2016-05-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-05-04, with a file datestamp of 2016-04-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5eola_
  • Heterogens: 5QO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eolA (A:)
mahhhhhhdevdgplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwge
lpngtrvpmevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergal
qeelarsffwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvyt
dfdgtrvysppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrv
ssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlh

    Sequence, based on observed residues (ATOM records): (download) 
    >5eolA (A:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlh