PDB entry 5ehr

View 5ehr on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Phosphatase PTP Inhibitor PTPN11 Allosteric, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2015-10-28, released 2016-06-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-07-20, with a file datestamp of 2016-07-15.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ehra1, d5ehra2, d5ehra3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ehrb1, d5ehrb2, d5ehrb3
  • Heterogens: 5OD, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ehrA (A:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ehrA (A:)
    rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
    dlyggekfatlaelvqyymehielkyplncadptserwfhghlsgkeaeklltekgkhgs
    flvresgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlvehykknpmvetlg
    tvlqlkqplnttrinaaeiesrvrelsklakqgfweefetlqqqeckllysrkegqrqen
    knknryknilpfdhtrvvlhdgdpnepvsdyinaniimpefkpkksyiatqgclqntvnd
    fwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlre
    lklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcs
    agigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqh
    yietl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5ehrB (B:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ehrB (B:)
    rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
    dlyggekfatlaelvqyymeielkyplncadptserwfhghlsgkeaeklltekgkhgsf
    lvresshpgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknpmvetlg
    tvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknk
    nryknilpfdhtrvvlhvsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivm
    ttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertv
    wqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividil
    idiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl