PDB entry 5ehp

View 5ehp on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP836
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Phosphatase PTP Inhibitor PTPN11 Allosteric, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2015-10-28, released 2016-07-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-09-21, with a file datestamp of 2016-09-16.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ehpa1, d5ehpa2, d5ehpa3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ehpb1, d5ehpb2, d5ehpb3
  • Heterogens: 5OA, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ehpA (A:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ehpA (A:)
    srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
    ydlyggekfatlaelvqyymehqlkekngdvielkyplncadptserwfhghlsgeaekl
    ltekgkhgsflvresshpgdfvlsvrtgskvthvmircqelkydvgggerfdsltdlveh
    ykknpmvelgtvlqlkqplnttrinaaeiesrvrelsklakqgfweefetlqqqecklly
    srkegqrqenknknryknilpfdhtrvvlhdgpnepvsdyinaniimpefkpkksyiatq
    gclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkes
    aahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimd
    agpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqy
    rfiymavqhyietl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5ehpB (B:)
    smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
    gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
    keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
    dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
    tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
    pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
    vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
    frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
    rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ehpB (B:)
    rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
    dlyggekfatlaelvqyymeqlkdvielkyplncadptserwfhghlsgkeaeklltekg
    khgsflvresdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknpmvetl
    gtvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenkn
    knryknilpfdhtrvvlhvsdyinaniimpksyiatqgclqntvndfwrmvfqensrviv
    mttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntert
    vwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividi
    lidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl