PDB entry 5egs

View 5egs on RCSB PDB site
Description: Human PRMT6 with bound fragment-type inhibitor
Class: transferase
Keywords: Fragment, Inhibitor, PRMT, transferase
Deposited on 2015-10-27, released 2016-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-06-22, with a file datestamp of 2016-06-17.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96LA8 (Start-375)
      • conflict (194)
    Domains in SCOPe 2.07: d5egsa_
  • Chain 'B':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96LA8 (Start-375)
      • conflict (194)
    Domains in SCOPe 2.07: d5egsb_
  • Chain 'C':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96LA8 (Start-375)
      • conflict (194)
    Domains in SCOPe 2.07: d5egsc_
  • Chain 'D':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96LA8 (Start-375)
      • conflict (194)
    Domains in SCOPe 2.07: d5egsd_
  • Heterogens: SAH, 5NR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5egsA (A:)
gmsqpkkrklesggggeggegteeedgaereaalerprrtkrerdqlyyecysdvsvhee
miadrvrtdayrlgilrnwaalrgktvldvgagtgilsifcaqagarrvyaveasaiwqq
arevvrfngledrvhvlpgpvetvelpeqvdaivsewmgygllhesmlssvlhartkwlk
egglllpasaelfivpisdqmlewrlgfwsqvkqhygvdmsclegfatrclmghseivvq
glsgedvlarpqrfaqlelsragleqeleagvggrfrcscygsapmhgfaiwfqvtfpgg
esekplvlstspfhpathwkqallylnepvqveqdtdvsgeitllpsrdnprrlrvllry
kvgdqeektkdfamed

    Sequence, based on observed residues (ATOM records): (download) 
    >5egsA (A:)
tkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrgktvldvgagtgilsi
fcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetvelpeqvdaivsewmg
ygllhesmlssvlhartkwlkegglllpasaelfivpisdqmlewrlgfwsqvkqhygvd
msclegfatrclmghseivvqglsgedvlarpqrfaqlelsragleqeleagvggrfrcs
cygsapmhgfaiwfqvtfpggekplvlstspfhpathwkqallylnepvqveqdtdvsge
itllpsrdnprrlrvllrykvgdqeektkdfamed

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5egsB (B:)
gmsqpkkrklesggggeggegteeedgaereaalerprrtkrerdqlyyecysdvsvhee
miadrvrtdayrlgilrnwaalrgktvldvgagtgilsifcaqagarrvyaveasaiwqq
arevvrfngledrvhvlpgpvetvelpeqvdaivsewmgygllhesmlssvlhartkwlk
egglllpasaelfivpisdqmlewrlgfwsqvkqhygvdmsclegfatrclmghseivvq
glsgedvlarpqrfaqlelsragleqeleagvggrfrcscygsapmhgfaiwfqvtfpgg
esekplvlstspfhpathwkqallylnepvqveqdtdvsgeitllpsrdnprrlrvllry
kvgdqeektkdfamed

    Sequence, based on observed residues (ATOM records): (download) 
    >5egsB (B:)
rtkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrgktvldvgagtgils
ifcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetvelpeqvdaivsewm
gygllhesmlssvlhartkwlkegglllpasaelfivpisdqmlewrlgfwsqvkqhygv
dmsclegfatrclmghseivvqglsgedvlarpqrfaqlelsragleqeleagvggrfrc
scygsapmhgfaiwfqvtfpggesekplvlstspfhpathwkqallylnepvqveqdtdv
sgeitllpsrdnprrlrvllrykvgdqeektkdfamed

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5egsC (C:)
gmsqpkkrklesggggeggegteeedgaereaalerprrtkrerdqlyyecysdvsvhee
miadrvrtdayrlgilrnwaalrgktvldvgagtgilsifcaqagarrvyaveasaiwqq
arevvrfngledrvhvlpgpvetvelpeqvdaivsewmgygllhesmlssvlhartkwlk
egglllpasaelfivpisdqmlewrlgfwsqvkqhygvdmsclegfatrclmghseivvq
glsgedvlarpqrfaqlelsragleqeleagvggrfrcscygsapmhgfaiwfqvtfpgg
esekplvlstspfhpathwkqallylnepvqveqdtdvsgeitllpsrdnprrlrvllry
kvgdqeektkdfamed

    Sequence, based on observed residues (ATOM records): (download) 
    >5egsC (C:)
tkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrgktvldvgagtgilsi
fcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetvelpeqvdaivsewmg
ygllhesmlssvlhartkwlkegglllpasaelfivpisdqmlewrlgfwsqvkqhygvd
msclegfatrclmghseivvqglsgedvlarpqrfaqlelsragleqeleagvggrfrcs
cygsapmhgfaiwfqvtfpggesekplvlstspfhpathwkqallylnepvqveqdtdvs
geitllpsrdnprrlrvllrykvgdqeektkdfamed

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5egsD (D:)
gmsqpkkrklesggggeggegteeedgaereaalerprrtkrerdqlyyecysdvsvhee
miadrvrtdayrlgilrnwaalrgktvldvgagtgilsifcaqagarrvyaveasaiwqq
arevvrfngledrvhvlpgpvetvelpeqvdaivsewmgygllhesmlssvlhartkwlk
egglllpasaelfivpisdqmlewrlgfwsqvkqhygvdmsclegfatrclmghseivvq
glsgedvlarpqrfaqlelsragleqeleagvggrfrcscygsapmhgfaiwfqvtfpgg
esekplvlstspfhpathwkqallylnepvqveqdtdvsgeitllpsrdnprrlrvllry
kvgdqeektkdfamed

    Sequence, based on observed residues (ATOM records): (download) 
    >5egsD (D:)
rtkrerdqlyyecysdvsvheemiadrvrtdayrlgilrnwaalrgktvldvgagtgils
ifcaqagarrvyaveasaiwqqarevvrfngledrvhvlpgpvetvelpeqvdaivsewm
gygllhesmlssvlhartkwlkegglllpasaelfivpisdqmlewrlgfwsqvkqhygv
dmsclegfatrclmghseivvqglsgedvlarpqrfaqlelsragleqeleagvggrfrc
scygsapmhgfaiwfqvtfpggplvlstspfhpathwkqallylnepvqveqdtdvsgei
tllpsrdnprrlrvllrykvgdqeektkdfamed