PDB entry 5egm

View 5egm on RCSB PDB site
Description: Development of a novel tricyclic class of potent and selective FIXa inhibitors
Class: hydrolase/hydrolase inhibitor
Keywords: SERINE PROTEINASE, BLOOD COAGULATION, COAGULATION FACTOR, HYDROLASE-2 HYDROLASE INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2015-10-27, released 2015-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor ix
    Species: Homo sapiens [TaxId:9606]
    Gene: F9
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00740 (0-234)
      • engineered mutation (137)
    Domains in SCOPe 2.08: d5egma_
  • Chain 'B':
    Compound: coagulation factor ix
    Species: Homo sapiens [TaxId:9606]
    Gene: F9
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5egmb_
  • Heterogens: NA, NHE, 5NY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5egmA (A:)
    vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
    tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
    kfgsgyvsgwgrvfhkgasalvlqylrvplvdratclrstkftiynnmfcagfheggrds
    cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5egmB (B:)
    mdvtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtskl
    tr
    

    Sequence, based on observed residues (ATOM records): (download)
    >5egmB (B:)
    vtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsq