PDB entry 5egm
View 5egm on RCSB PDB site
Description: Development of a novel tricyclic class of potent and selective FIXa inhibitors
Class: hydrolase/hydrolase inhibitor
Keywords: SERINE PROTEINASE, BLOOD COAGULATION, COAGULATION FACTOR, HYDROLASE-2 HYDROLASE INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2015-10-27, released
2015-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
- Uniprot P00740 (0-234)
- engineered mutation (137)
Domains in SCOPe 2.08: d5egma_ - Chain 'B':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5egmb_ - Heterogens: NA, NHE, 5NY, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>5egmA (A:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgasalvlqylrvplvdratclrstkftiynnmfcagfheggrds
cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5egmB (B:)
mdvtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtskl
tr
Sequence, based on observed residues (ATOM records): (download)
>5egmB (B:)
vtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsq