PDB entry 5eg3

View 5eg3 on RCSB PDB site
Description: Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)
Class: Transferase/Hydrolase
Keywords: Signaling Complex, Tyrosine Kinase domain, SH2 domain, Recruitment, Phosphorylation, Transferase-Hydrolase complex
Deposited on 2015-10-26, released 2016-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-13, with a file datestamp of 2017-09-08.
Experiment type: XRAY
Resolution: 2.61 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (21)
      • engineered mutation (46)
      • engineered mutation (120)
      • engineered mutation (211-212)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d5eg3a_
  • Chain 'B':
    Compound: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: PLCG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10686 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d5eg3b_
  • Heterogens: ACP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eg3A (A:)
mgsshhhhhhsqdpmlagvsefelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
ayaskgnlreylrarrppgmelspdinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidffkettngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttneeyldlsqpleq

    Sequence, based on observed residues (ATOM records): (download) 
    >5eg3A (A:)
felpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddate
kdlsdlvsememmkmigkhkniinllgactqdgplyvivayaskgnlreylrarrppgnr
vpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardin
nidffkettngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveel
fkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlttneeyldl
sq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5eg3B (B:)
mnaheskewyhasltraqaehmlmrvprdgaflvrkrnepnsyaisfraegkikhcrvqq
egqtvmlgnsefdslvdlisyyekhplyrkmklrypineealekigtaepdyga

    Sequence, based on observed residues (ATOM records): (download) 
    >5eg3B (B:)
mnaheskewyhasltraqaehmlmrvprdgaflvrkrnepnsyaisfraegkikhcrvqq
egqtvmlgnsefdslvdlisyyekhplyrkmklrypineealekigtaepdyg