PDB entry 5ear

View 5ear on RCSB PDB site
Description: Crystal structure of human WDR5 in complex with compound 9d
Class: transcription / transcription inhibitor
Keywords: WDR5, compound 9d, Structural Genomics, Structural Genomics Consortium, SGC, TRANSCRIPTION - TRANSCRIPTION INHIBITOR complex
Deposited on 2015-10-16, released 2015-11-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-23, with a file datestamp of 2018-05-18.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5eara_
  • Chain 'B':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5earb_
  • Heterogens: 5MQ, EDO, UNX, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5earA (A:)
gtqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekt
isghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsn
livsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtas
gqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyci
fanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaale
ndktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >5earA (A:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
nppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtggkw
ivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwksd
c

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5earB (B:)
gtqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekt
isghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsn
livsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtas
gqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyci
fanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaale
ndktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >5earB (B:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
dppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtggkw
ivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklwksd
c