PDB entry 5eai

View 5eai on RCSB PDB site
Description: Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a
Class: oxidoreductase
Keywords: NQO1, two-electron reduction of Quinone, NAD(P)H dehydrogenase, dimeric naphthoquinone, OXIDOREDUCTASE
Deposited on 2015-10-16, released 2016-02-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-02-17, with a file datestamp of 2016-02-12.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaia_
  • Chain 'B':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaib_
  • Chain 'C':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaic_
  • Chain 'D':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaid_
  • Chain 'E':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaie_
  • Chain 'F':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaif_
  • Chain 'G':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaig_
  • Chain 'H':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaih_
  • Chain 'I':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaii_
  • Chain 'J':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaij_
  • Chain 'K':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaik_
  • Chain 'L':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eail_
  • Chain 'M':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eaim_
  • Chain 'N':
    Compound: nad(p)h dehydrogenase [quinone] 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO1, DIA4, NMOR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5eain_
  • Heterogens: FAD, E6A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5eaiA (A:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiA (A:)
    rralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkdp
    anfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfig
    efaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgfq
    vlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkkev
    qdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5eaiB (B:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiB (B:)
    rralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkdp
    anfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfig
    efaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgfq
    vlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkkev
    qdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5eaiC (C:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiC (C:)
    vgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklk
    dpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervf
    igefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcg
    fqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkk
    evqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5eaiD (D:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiD (D:)
    rralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkdp
    anfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfig
    efaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgfq
    vlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkkev
    qdeeknkkfglsvghhlgksiptdnqikark
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >5eaiE (E:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiE (E:)
    grralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkd
    panfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfi
    gefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgf
    qvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkke
    vqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >5eaiF (F:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiF (F:)
    grralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkd
    panfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfi
    gefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgf
    qvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkke
    vqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5eaiG (G:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiG (G:)
    vgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklk
    dpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervf
    igefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcg
    fqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkk
    evqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >5eaiH (H:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiH (H:)
    grralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkd
    panfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfi
    gefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgf
    qvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkke
    vqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >5eaiI (I:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiI (I:)
    vgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklk
    dpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervf
    igefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcg
    fqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkk
    evqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >5eaiJ (J:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiJ (J:)
    grralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkd
    panfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfi
    gefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgf
    qvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkke
    vqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >5eaiK (K:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiK (K:)
    grralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkd
    panfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfi
    gefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgf
    qvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkke
    vqdeeknkkfglsvghhlgksiptdnqikar
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >5eaiL (L:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiL (L:)
    vgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklk
    dpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervf
    igefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcg
    fqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkk
    evqdeeknkkfglsvghhlgksiptdnqikark
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >5eaiM (M:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiM (M:)
    vgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklk
    dpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervf
    igefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcg
    fqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkk
    evqdeeknkkfglsvghhlgksiptdnqikark
    

  • Chain 'N':
    Sequence, based on SEQRES records: (download)
    >5eaiN (N:)
    gphmvgrralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkdit
    gklkdpanfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwf
    ervfigefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgil
    hfcgfqvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagf
    lmkkevqdeeknkkfglsvghhlgksiptdnqikark
    

    Sequence, based on observed residues (ATOM records): (download)
    >5eaiN (N:)
    grralivlahsertsfnyamkeaaaaalkkkgwevvesdlyamnfnpiisrkditgklkd
    panfqypaesvlaykeghlspdivaeqkkleaadlvifqfplqwfgvpailkgwfervfi
    gefaytyaamydkgpfrskkavlsittggsgsmyslqgihgdmnvilwpiqsgilhfcgf
    qvlepqltysightpadariqilegwkkrleniwdetplyfapsslfdlnfqagflmkke
    vqdeeknkkfglsvghhlgksiptdnqikar